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Original Article |

Planum Temporale and Heschl Gyrus Volume Reduction in Schizophrenia:  A Magnetic Resonance Imaging Study of First-Episode Patients FREE

Yoshio Hirayasu, MD, PhD; Robert W. McCarley, md; Dean F. Salisbury, PhD; Shin Tanaka, md; Jun Soo Kwon, MD, PhD; Melissa Frumin, md; Danielle Snyderman, BS; Deborah Yurgelun-Todd, PhD; Ron Kikinis, md; Ferenc A. Jolesz, md; Martha E. Shenton, PhD
[+] Author Affiliations

From the Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, Brockton Veterans Affairs Medical Center, and Harvard Medical School, Brockton, Mass (Drs Hirayasu, McCarley, Salisbury, Tanaka, Kwon, Frumin, and Shenton and Ms Snyderman); Cognitive Neuroscience Laboratory, McLean Hospital (Drs McCarley, Salisbury, and Shenton), and Brain Imaging Center, McLean Hospital (Dr Yurgelun-Todd), Belmont, Mass; and The Surgical Planning Laboratory, MRI Division, Brigham and Women's Hospital, Department of Radiology, Harvard Medical School, Boston, Mass (Drs Kikinis and Jolesz). Dr Hirayasu is now with the Department of Neuropsychiatry, Kyorin University School of Medicine, Tokyo, Japan. Dr Kwon is now with the Department of Psychiatry, Seoul National University Medical College, Seoul, Korea.


Arch Gen Psychiatry. 2000;57(7):692-699. doi:10-1001/pubs.Arch Gen Psychiatry-ISSN-0003-990x-57-7-yoa9242.
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Published online

Background  Magnetic resonance imaging studies in schizophrenia have revealed abnormalities in temporal lobe structures, including the superior temporal gyrus. More specifically, abnormalities have been reported in the posterior superior temporal gyrus, which includes the Heschl gyrus and planum temporale, the latter being an important substrate for language. However, the specificity of the Heschl gyrus and planum temporale structural abnormalities to schizophrenia vs affective psychosis, and the possible confounding roles of chronic morbidity and neuroleptic treatment, remain unclear.

Methods  Magnetic resonance images were acquired using a 1.5-T magnet from 20 first-episode (at first hospitalization) patients with schizophrenia (mean age, 27.3 years), 24 first-episode patients with manic psychosis (mean age, 23.6 years), and 22 controls (mean age, 24.5 years). There was no significant difference in age for the 3 groups. All brain images were uniformly aligned and then reformatted and resampled to yield isotropic voxels.

Results  Gray matter volume of the left planum temporale differed among the 3 groups. The patients with schizophrenia had significantly smaller left planum temporale volume than controls (20.0%) and patients with mania (20.0%). Heschl gyrus gray matter volume (left and right) was also reduced in patients with schizophrenia compared with controls (13.1%) and patients with bipolar mania (16.8%).

Conclusions  Compared with controls and patients with bipolar manic psychosis, patients with first-episode schizophrenia showed left planum temporale gray matter volume reduction and bilateral Heschl gyrus gray matter volume reduction. These findings are similar to those reported in patients with chronic schizophrenia and suggest that such abnormalities are present at first episode and are specific to schizophrenia.

Figures in this Article

STRUCTURAL brain abnormalities in schizophrenia have been extensively investigated using magnetic resonance imaging (MRI).15 Several studies have reported abnormalities in portions of the superior temporal gyrus (STG) in patients diagnosed as having schizophrenia,13 including planum temporale (PT) and Heschl gyrus (HG) (primary auditory cortex).614 The impetus for much of this work is based on the role that the left (dominant) hemisphere PT plays in language processing1517 and the role that the HG plays in the initial processing of auditory information.13

DeLisi et al10 measured length of the sylvian fissure and reported asymmetry differences in patients with first-episode schizophrenia compared with controls. Reduced cortical PT volume was reported in a postmortem study in schizophrenia compared with controls,18 and we reported reduced left PT gray matter volume and a reversal of PT asymmetry in patients diagnosed as having chronic schizophrenia.6 Other investigators7,8 measuring PT area in schizophrenia also reported a reversal of the left larger than right PT asymmetry found in controls. However, several investigators913 have not reported abnormalities of PT asymmetry in schizophrenia. Of particular note, Kleinschmidt and colleagues11 reported no differences in PT area between first-episode patients with schizophrenia and controls. This lack of consistency in results is likely due to variations in the definition of PT, as discussed by Barta and coworkers.19

Fewer studies of HG have been conducted, although asymmetrical length has been reported in HG (left greater than right) in healthy patients in a postmortem study by Musiek and Reeves.20 Only one group21 using MRI has reported a left HG volume greater than the right in controls and patients with paranoid schizophrenia. However, other investigators7,12,14 have reported no asymmetry between left and right HG and no difference in asymmetry between patients with schizophrenia and controls. To our knowledge, no studies have evaluated gray matter volume of HG and PT concurrently in patients with schizophrenia and those with affective psychosis at the time of first hospitalization.

It remains uncertain whether the psychosis associated with affective disorder and schizophrenia represents manifestations of different disorders or variants of a single disorder with somewhat different expressions.22 The MRI studies that evaluate both patient groups may assist in answering this question. We previously reported23 that first-episode patients with schizophrenia showed smaller gray matter volume in a posterior segment of STG than first-episode patients with affective disorder and controls. The MRI evidence also supporting pathophysiological differences comes from Pearlson and colleagues,24 who reported STG and medial temporal lobe abnormalities in patients with schizophrenia but not in patients with bipolar disorder.

The posterior STG segment, reported previously by us, included only a fraction of the whole PT, and HG was not evaluated. In the present study, gray matter volume of PT and HG was measured to determine whether PT and HG abnormalities are present at first episode and specific to schizophrenia as contrasted with first-episode manic psychosis.

SUBJECTS

Patients were inpatients at McLean Hospital, a private psychiatric hospital in Belmont, Mass. Thirty-five psychotic patients were tested within 2 weeks of their first hospitalization, 8 within 4 months of first hospitalization, and 1 within 11 months. Patients and control subjects met criteria for age (18-55 years), IQ above 75, right-handedness,25 negative history of seizures, head trauma with loss of consciousness, neurologic disorder, and no lifetime history of alcohol or other drug dependence. Control subjects had no Axis I mental disorder nor did their first-degree relatives (self-report).

Patients were diagnosed using the Structured Clinical Interview for DSM-III-R (SCID),26 a review of hospital course, and medical records. The study group consisted of 20 patients with schizophrenia (16 men, 4 women) and 24 patients with bipolar disorder mania with psychotic features (18 men, 6 women). All patients manifested psychosis at the time of the study. More specifically, 6 patients with schizophrenia had hallucinations, paranoia, ideas of reference, and delusions; 1 had hallucinations, delusions, and ideas of reference; 2 had hallucinations, paranoia, and ideas of reference; 2 had hallucinations and delusions; 2 had delusions and paranoia; 2 had hallucinations and paranoia; 2 had only hallucinations; and 3 had only delusions. Two patients with mania had hallucinations, paranoia, ideas of reference, and delusions; 5 had hallucinations, delusions, and ideas of reference; 2 had hallucinations, paranoia, and delusions; 1 had hallucinations and delusions; 1 had hallucinations and ideas of reference; 2 had delusions and paranoia; 5 had delusions and ideas of reference; 5 had only delusions; and 1 had only paranoia. Diagnoses were confirmed at 1-year follow-up. The median duration of psychotropic medication use before MRI was short (Table 1). In addition, duration of medication use and dosage of medication were not significantly correlated with any MRI volumes. In terms of operationalizing onset of psychosis, we selected date of first psychiatric hospitalization. Although onset of prodromal symptoms may be a better indicator of actual onset of disease, in practice this retrospective measure is difficult to verify. For comparative purposes, we provided age at time of first medication use, which we believe to be more objective (most dates were from hospital records) and nonequivocal than prodrome onset and thus possibly a better estimate of symptom onset. A group of 22 control subjects (SCID nonpatient edition27 and SCID-II28; 20 men, 2 women), group matched for age, was recruited through newspaper advertisements. The present study reflects an increase in sample size (N=64) over our previous study (N=46)23 and presents new, more detailed measures of posterior STG anatomy, partially but not completely coextensive with our previous measures of posterior STG.

Table Graphic Jump LocationTable 1. Subjects' Characteristics and Test Scores*

The Mini-Mental State Examination was used to rule out dementia or delirium. In addition, the information subscale of the Wechsler Adult Intelligence Scale–Revised29 was used to estimate general information, and the digits-forward and -backward subscales of the Wechsler Adult Intelligence Scale–Revised were used to evaluate immediate and short-term memory, attention, and concentration. Socioeconomic status (SES) and parental SES30 were also assessed. Psychosis was further evaluated using the Brief Psychiatric Rating Scale (BPRS).31 Social functioning was evaluated using the Global Assessment Scale32 (Table 1). After a complete description of the study, written informed consent was obtained from all subjects. Subjects were paid for participating.

MRI ACQUISITION PROTOCOL AND MRI POSTPROCESSING

The MRIs were obtained on a 1.5-T scanner (General Electric Scanner; GE Medical Systems, Milwaukee, Wis). Details concerning pulse sequences are provided elsewhere.3335 Briefly, there were 2 MRI protocols. The first was a coronal series of contiguous images (repetition time=35 milliseconds, echo time=5 milliseconds, 1 repetition, 45° nutation angle, 24-cm field of view, number of excitations=1.0, matrix=256×256[192 phase encoding steps]×124). Voxel (volume of pixel) dimensions were 0.9375×0.9375× 1.5 mm. Data were reformatted in the coronal plane and analyzed as 124 coronal 1.5-mm-thick slices. This protocol was used to measure PT and HG. The second was an axial series of contiguous double echo (proton density and T2-weighted) images (repetition time=3000 milliseconds, echo time=30 and 80 milliseconds, 24-cm field of view, an interleaved acquisition with 3-mm slice thickness). Voxel dimensions were 0.9375×0.9375×3 mm. This latter protocol was used to evaluate total intracranial volume. To reduce flow-related artifacts and to obtain low arterial signal intensity, presaturation of a slab inferior to the head was performed in both the axial and coronal acquisitions. A semiautomated segmentation procedure33 was used on the axial slices to measure total intracranial content (ICC), including overall gray matter, white matter, and cerebrospinal fluid. An anisotropic diffusion filter was applied to reduce noise before processing each set of scans.35

REALIGNMENT AND RESAMPLING PROCESS

Following acquisition, MRIs were aligned using the interhemispheric fissure in the anterior two thirds of the brain in the coronal and axial planes. After this alignment in 2 planes, the midsagittal plane was aligned to correct head tilt using the line between the anterior and posterior commissures. Images were also resampled using an algorithm to make them isotropic, with sides measuring 0.9375 mm. Comparisons in 5 patients with schizophrenia and 5 healthy subjects showed that this process did not alter either measured region of interest (ROI) volumes or segmentation values for gray matter, white matter, or cerebrospinal fluid.

DEFINITION OF HG AND PT

The ROI definitions for both PT and HG have been described in detail by us in a recent study.6 In the present study, we used criteria similar to both our previous work and to the work of Barta et al19 for delineating HG and PT. We defined HG as the first transverse gyrus commencing from a point at the posterior margin of the insula next to the end of an opercular branch of the postcentral gyrus, then traversing anterolaterally to the superior aspect of the temporal lobe and terminating at the lateral border of STG. If there was an initial single gyral origin of HG, and then bifurcation into branches, both branches were defined as HG.

Briefly summarized, our ROI definition procedure involved first using axial MRIs for manually outlining HG. The marked voxels defining the axial HG outlines, once reformatted, helped to accurately pinpoint the location of HG on the coronal images, with HG tracing proceeding from the most posterior coronal image with a mark to the most anterior. In between these bounds, we manually outlined HG gray matter. As the Heschl sulcus reached the lateral border of STG, we included only the edge of gray matter of HG superior to the level of the white matter, ie, the roof of the white matter of STG was the inferior boundary of HG gray matter, and the most lateral extension of white matter formed the lateral bound of HG. Finally, sagittal MRIs were used to check and confirm HG boundaries.

The anterior border of PT was defined by the posterior border of HG. The lateral border of PT was defined as the superolateral margin of STG, with the gray matter underneath being manually outlined. Posteriorly, PT gray matter was traced to the end of the sylvian fissure, as seen on coronal images, and then gray matter of the ascending ramus of the sylvian fissure was also included. Thus, our definition of the PT included PT proper and its parietal extension. Both PT and HG ROIs could then be viewed as 3-dimensional objects for any further editing (Figure 1).

Place holder to copy figure label and caption
Figure 1.

A, Coronal slice (1.5 mm) through the temporal lobe of a healthy control subject. The regions of interest for the structures are outlined: the gray matter of Heschl gyrus (HG) is red on subject left and green on subject right. The gray matter of planum temporale (PT) is labeled yellow on subject left and blue on subject right. B, Top-down view of the 3-dimensional reconstruction of HG and PT placed on top of an axial magnetic resonance imaging slice. Anterior is top. The HG is red on subject left and green on subject right, and PT is blue on subject left and yellow on subject right. C, Three-dimensional reconstruction of the left and right regions of interest, color coded as in section B but from a slightly different angle of rotation from that in section B. Note the tubular structure of the gray matter of the superior temporal gyrus, most clearly seen anteriorly, where gray codes non-HG, non-PT portions of superior temporal gyrus. D, Three-dimensional reconstructions viewed from a different angle from that in section C (D1 is subject right and D2 is subject left).

Graphic Jump Location

Interrater reliability was computed for the ROIs by 3 independent raters (Y.H., S.T., and D.S.) who were blind to group membership. Ten cases were randomly selected for interrater reliability. An intraclass correlation coefficient was used to compute interrater reliability based on the 3 raters: 0.882 (left HG), 0.881 (right HG), 0.985 (left PT), and 0.950 (right PT).

STATISTICAL ANALYSES

One-way analysis of variance was used to test for group differences in age, SES, and parental SES. In addition, t tests were used to assess group differences in clinical measures, age of first medication use, and medication dose and duration of use. Tests for group differences in ICC were conducted with a 1-way analysis of covariance (ANCOVA), with age and parental SES as covariates.

For ROI analysis we used a mixed-model ANCOVA, using relative volumes with 1 between-subjects factor (group: schizophrenia, mania, or controls) and 2 within-subjects factors (side: left and right; region: HG and PT). Age and parental SES were used as covariates for all ANCOVAs. Follow-up analyses included a 2-factor (group and side) ANCOVA for each region (HG and PT), 1-way ANCOVA, and post hoc Tukey Honestly Significant Difference tests for individual regions, with left and right compared separately. For the analyses used herein, we used relative volumes of ROI computed as [(absolute ROI volume)/(ICC)]×100. Adjusting for brain size by linear regression of absolute volumes on ICC and using the residuals for comparisons did not change the results reported herein (see Zipursky et al36 and Dickey et al37 for examples of this procedure).

Exploratory analyses of the relationship between absolute volumes of PT and HG and the 4 syndrome factors of the BPRS,38 as well as for each BPRS item, were evaluated using Spearman rho.

There were no significant group differences in age. First-episode patients with schizophrenia showed significantly lower SES than comparison subjects, consistent with reduced functioning (Table 1). Parental SES was upper middle class or above for all groups, but parental SES of the schizophrenia group was lower than parental SES of the other 2 comparison groups. There were no significant differences between patients diagnosed as having schizophrenia and patients diagnosed as having mania on any of the clinical scale measures, age of first medication use, medication dose, or duration of illness. There were significant differences between the patient groups in 4 items of the BPRS. Patients with schizophrenia showed higher scores (mean±SD) in suspiciousness (schizophrenia, 4.26±1.88; mania, 2.96±2.14; t42=2.07; P=.04), hallucinatory behavior (schizophrenia, 3.05±1.81; mania, 2.00±1.01; t42=2.06; P=.046), and blunted affect (schizophrenia, 3.11±1.76; mania, 1.70±1.40; t42=2.84; P=.007) than patients with mania. In contrast, patients with mania showed higher scores for grandiosity (schizophrenia, 1.42±3.01; mania, 3.83±1.02; t42=3.32; P=.002). Total score on the BPRS, age of first medication use, and duration of medication use did not correlate with any ROI volumes. There was also no significant difference in ICC volume among the 3 groups.

VOLUME OF THE PT AND HG

The 3-factor ANCOVA revealed a significant group-by-side-by-region interaction (F2,61=4.41, P=.02). Follow-up ANCOVA revealed a significant group-by-side interaction (F2,61=7.62, P=.001) in PT. One-way ANCOVA showed that left PT differed among groups (F2,61=4.76, P=.01), with the schizophrenia group significantly smaller than the control and mania groups (Tukey Honestly Significant Difference, P<.05) (Table 2 and Figure 2). However, right PT was not different among groups.

Table Graphic Jump LocationTable 2. Absolute and Relative Volumes of Regions of Interest of Heschl Gyrus and Planum Temporale*
Place holder to copy figure label and caption
Figure 2.

Relative volume of the Heschl gyrus and planum temporale in patients with first-episode schizophrenia, patients with first-episode mania, and healthy control subjects. Horizontal lines represent means.

Graphic Jump Location

For HG, there was a significant main effect for group (F2,61=4.67, P=.01), with no group-by-side interaction (F2,61=0.21, P=.98). Post hoc tests revealed that total (left and right) HG gray matter volume was significantly smaller in schizophrenic patients compared with patients with mania and healthy control subjects (Tukey Honestly Significant Difference, P<.05) but that group differences for left and right HG did not reach significance by 1-way ANCOVA (F2,61=2.11, P=.13; F2,61=2.49, P=.09, respectively) (Table 2 and Figure 2). However, HG was significantly asymmetrical in all subjects (F1,61=4.19, P=.04).

Note that, compared with controls and patients with mania, patients with schizophrenia show gray matter volume reductions of 20.0% in left PT (effect size=0.91). In addition, compared with controls, patients with schizophrenia show gray matter volume reductions of 15.3% in left HG (effect size=0.71) and 10.6% in right HG (effect size=0.44). For HG (left+right), patients with schizophrenia, compared with controls and patients with mania, showed 13.1% (effect size=0.87) and 16.8% (effect size=1.16) volume reduction, respectively.

CORRELATIONS BETWEEN ROI VOLUMES AND PSYCHOPATHOLOGY

In an exploratory analysis, no factors or items of the BPRS significantly correlated (P<.05) with absolute or relative volumes of PT or HG in first-episode schizophrenia or in first-episode mania. In addition, none of the cognitive tests were statistically significantly correlated with HG and PT volumes in this study.

Left PT gray matter volume was significantly reduced in first-episode patients with schizophrenia compared with controls (20.0%) and first-episode patients with manic psychosis (20.0%). Bilateral HG gray matter volume was also reduced in patients with schizophrenia compared with controls and patients with mania.

The present data are consistent with our earlier findings of left-lateralized volume reduction in posterior STG gray matter in both chronic and first-episode schizophrenia23,33 and enlarges the finding, since the region studied previously was only partially coextensive with PT. These data are also consistent with left PT gray matter volume reduction (28.2%) in patients with chronic schizophrenia.6 The present findings suggest that lateralized PT reductions are not due to confounds of long-term medication use or disorder chronicity and that abnormal left PT and bilateral HG gray matter volumes are present at time of first hospitalization and are specific to schizophrenia.

Musiek and Reeves20 reported an asymmetrical length of HG (left greater than right) in healthy subjects. However, findings have been inconsistent in MRI studies of schizophrenia.7,12,14 Rojas and coworkers,21 for example, reported a left HG volume greater than the right in controls and patients diagnosed as having paranoid schizophrenia. The present results indicate an asymmetry of HG in all groups but also suggest bilateral HG reduction in the schizophrenia group. This raises the interesting question of primary auditory sensory deficits in schizophrenia, a question not yet completely investigated. For example, Holcomb and coworkers39 have documented that patients with schizophrenia have more difficulty than controls in differentiating high and low tones presented against a background of noise, and these patients often also show deficits in mismatch negativity, an electrophysiological index of echoic memory processes.40,41

In the present study, clinical measures and ROIs were not significantly correlated. In patients with chronic disease, left anterior STG volume reduction has been reported to correlate with auditory hallucinations,42 and left posterior STG volume reduction has been reported to correlate with severity of thought disorder.4,33 Moreover, our laboratory found the suspiciousness/persecution subscale score of the Positive and Negative Syndrome Scale was associated with reduced left PT volume in patients diagnosed as having chronic schizophrenia.6 Correlations between clinical measures and reduced volumes in patients with chronic schizophrenia have been reported by several investigators.36,43,44 However, few MRI studies45,46 of first-episode schizophrenia have reported an association between structural abnormalities and symptoms. We suggest that at the time of first hospitalization symptom-MRI correlations might be less than in chronic schizophrenia because of either a lack of stability in psychiatric symptoms or an absence of more marked structural alterations.

The specificity of MRI abnormalities to schizophrenic vs affective psychosis is a long-standing conundrum, as is the more general question of whether these psychoses are manifestations of a single disorder. Our previous report indicated that volume reduction in left posterior STG gray matter was specific to schizophrenia, although volume reduction of the posterior amygdala-hippocampal complex was not different between patients diagnosed as having first-episode schizophrenia and patients diagnosed as having first-episode bipolar mania. A recent report by Velakoulis et al47 also showed left hippocampal volume reduction in first-episode schizophrenia and schizophreniform psychosis compared with healthy subjects, but, once again, no differences were reported between first-episode schizophrenia and first-episode affective psychosis. These findings suggest that abnormalities in left STG gray matter, including PT and HG, are specific to schizophrenic psychosis, in contrast to abnormalities in medial temporal structures. Furthermore, Schlaepfer et al43 reported that patients with bipolar disorder did not show heteromodal cerebral cortex volume reduction, whereas gray matter volume was reduced in patients with schizophrenia. More specifically, asymmetry reversal was reported for posterior STG in patients diagnosed as having schizophrenia but not in patients diagnosed as having bipolar disorder.24 Zipursky et al48 similarly found global volume reduction in gray matter in first-episode psychotic patients but not in first-episode affective psychotic patients. Harvey et al49 also reported a decrease in cortical volume in patients with schizophrenia but not in patients with bipolar disorder. Since we have not investigated frontal or parietal cortex, 2 other areas possibly implicated in schizophrenic and affective pathology,1,2 conclusions drawn herein about specificity apply only to the regions we have studied.

There are several caveats to this study. First, the sex distribution of our sample did not allow us to investigate this variable. We anticipate doing so in the future. Second, a previous study by our group failed to show a significant volume difference in HG between patients with chronic schizophrenia and controls.6 One possible reason may be that different methods were used. In the previous study, post-MRI realignment was not performed, whereas in the present study we used a newly developed postrealignment procedure and a new method for resampling of voxels. When we evaluated the 2 methods, with and without realignment before ROI tracing (N=10; 5 patients with schizophrenia and 5 controls), we found no significant volume difference between the 2 methods for PT or HG in either schizophrenic patients or control subjects. We also found no differences in intraclass correlation coefficients between the 2 methods. A more likely explanation for the difference in HG and PT in this study, but for only PT in our previous study, might be the differences in the samples. Third, operationalizing first episode as time of first hospitalization rather than as time of prodromal symptom onset may overestimate age at onset yet provides an unequivocal measure. First hospitalization is used synonymously with first episode in virtually all the literature. We have also provided time of first medication use, which may help to clarify the clinical picture for patients with significant symptoms before hospitalization.

In conclusion, our findings of volume reduction in PT and HG in first-episode schizophrenia suggest the presence of structural abnormalities in regions associated with auditory processing and language. Finally, we suggest that studies of patients with recent-onset disease provide a major advantage in having fewer confounds from chronicity variables and, additionally, offer a baseline for longitudinal studies evaluating the presence or absence of progression of MRI changes over time.

Accepted for publication March 24, 2000.

This work was supported in part by grants NIMH 01110 and 50747 (Dr Shenton) and NIMH 40977 (Dr McCarley) from the National Institute of Mental Health, Rockville, Md; by MERIT and Schizophrenia Center Awards from the Department of Veterans Affairs Medical Research Service, Washington, DC (Dr McCarley); by a National Alliance for Research on Schizophrenia and Depression Young Investigator Award (Dr Salisbury); and by a Neuroimaging Analysis Center Biomedical Technology Resource grant (P41 RR13218-01) and Core Segmentation Tools for Computer Assisted Surgery grant (1R01 RR11747-01A) (Drs Kikinis and Jolesz).

Reprints: Martha E. Shenton, PhD, or Robert W. McCarley, MD, Department of Psychiatry (116A), VAMC-Brockton, Harvard Medical School, 940 Belmont St, Brockton, MA 02301 (e-mail: martha_shenton@hms.harvard.edu; robert_mccarley@hms.harvard.edu).

Shenton  MEWible  CGMcCarley  RW A review of magnetic resonance imaging studies of brain abnormalities in schizophrenia. Krishnan  KRRDoraiswamy  PMeds.Brain Imaging in Clinical Psychiatry New York, NY Marcel Dekker Inc1997;297- 380
McCarley  RWWible  CGFrumin  MHirayasu  YLevitt  JJFischer  IAShenton  ME MRI anatomy of schizophrenia. Biol Psychiatry. 1999;451099- 1119
Link to Article
Shenton  MEFrumin  MMcCarley  RWMaier  SWestin  CFFischer  IADickey  CCKikinis  R MR morphometric findings in schizophrenia. Dougherty  DRauch  SRosenbaum  Jeds.Psychiatric Neuroimaging Strategies Research and Clinical Applications Washington, DC American Psychiatric Association2000;
Pearlson  GDMarsh  L Structural brain imaging in schizophrenia: a selective review. Biol Psychiatry. 1999;46627- 649
Link to Article
Marsh  LSuddath  RLHiggins  NWeinberger  DR Medial temporal lobe structures in schizophrenia: relationship of size to duration of illness. Schizophr Res. 1994;11225- 238
Link to Article
Kwon  J-SMcCarley  RWHirayasu  YAnderson  JEFischer  IAKikinis  RJolesz  FAShenton  ME Left planum temporale volume reduction in schizophrenia. Arch Gen Psychiatry. 1999;56142- 148
Link to Article
Petty  RGBarta  PEPearlson  GDMcGilchrist  IKLewis  RWTien  AYPulver  AVaughn  DDCasanova  MFPowers  RE Reversal of asymmetry of the planum temporale in schizophrenia. Am J Psychiatry. 1995;152715- 721
Rossi  ASerio  AStratta  PPetruzzi  CSchiazza  GMancini  FCasacchia  M Planum temporale asymmetry and thought disorder in schizophrenia. Schizophr Res. 1994;121- 7
Link to Article
Jacobsen  LKGiedd  JNTanrikut  CBrady  DRDonohue  BCHamburger  SDKumra  SAlaghband-Rad  JRumsey  JMRapoport  JL Three-dimensional cortical morphometry of the planum temporale in childhood-onset schizophrenia. Am J Psychiatry. 1997;154685- 687
DeLisi  LEHoff  ALNeale  CKushner  M Asymmetries in the superior temporal lobe in male and female first-episode schizophrenic patients: measures of the planum temporale and superior temporal gyrus by MRI. Schizophr Res. 1994;1219- 28
Link to Article
Kleinschmidt  AFalkai  PHuang  YSchneider  TFurst  GSteinmetz  H In vivo morphometry of planum temporale asymmetry in first-episode schizophrenia. Schizophr Res. 1994;129- 18
Link to Article
Kulynych  JJVladar  KFantie  BDJones  DWWeinberger  DR Normal asymmetry of the planum temporale in patients with schizophrenia: three-dimensional cortical morphometry with MRI. Br J Psychiatry. 1995;166742- 749
Link to Article
Frangou  SSharma  TSigmudsson  TBarta  PPearlson  GMurray  RM The Maudsley Family Study, 4: normal planum temporale asymmetry in familial schizophrenia: a volumetric MRI study. Br J Psychiatry. 1997;170328- 333
Link to Article
Barta  PEPearlson  GDBrill  LB  IIRoyall  RMcGilchrist  IKPulver  AEPowers  RECasanova  MFTien  AYFrangou  SPetty  RG Planum temporale asymmetry reversal in schizophrenia: replication and relationship to gray matter abnormalities. Am J Psychiatry. 1997;154661- 667
Galaburda  AMCorsiglia  JRosen  GDSherman  GF Planum temporale asymmetry, reappraisal since Geschwind and Levitsky. Neuropsychologia. 1987;25853- 868
Link to Article
Geschwind  NLevitsky  W Human brain: left-right asymmetries in temporal speech region. Science. 1968;161186- 187
Link to Article
Witelson  SFPallie  W Left hemisphere specialization for language in the newborn: neuroanatomical evidence of asymmetry. Brain. 1973;96641- 646
Link to Article
Falkai  PBogerts  BSchneider  TGreve  BPfeiffer  UPilz  KGonsiorzcyk  CMajtenyi  COvary  I Disturbed planum temporale asymmetry in schizophrenia: a quantitative post-mortem study. Schizophr Res. 1995;14161- 176
Link to Article
Barta  PEPetty  RGMcGilchrist  ILewis  RWJerram  MCasanova  MFPowers  REBrill  LB  IIPearlson  GD Asymmetry of the planum temporale: methodological considerations and clinical associations. Psychiatry Res. 1995;61137- 150
Link to Article
Musiek  FEReeves  AG Asymmetries of the auditory areas of the cerebrum. J Am Acad Audiol. 1990;1240- 245
Rojas  DCTeale  PSheeder  JSimon  JReite  M Sex-specific expression of Heschl's gyrus functional and structural abnormalities in paranoid schizophrenia. Am J Psychiatry. 1997;1541655- 1662
Crow  TJ The two-syndrome concept: origins and current status. Schizophr Bull. 1985;11471- 486
Link to Article
Hirayasu  YShenton  MESalisbury  DFDickey  CCFischer  IAMazzoni  PKisler  TArakaki  HKwon  JSAnderson  JEYurgelun  TTohen  MMcCarley  RW Lower left temporal lobe MRI volumes in patients with first-episode schizophrenia compared with psychotic patients with first-episode affective disorder and normal subjects. Am J Psychiatry. 1998;1551384- 1391
Pearlson  GDBarta  PEPowers  REMenon  RRRichards  SSAylward  HFederman  BChase  GAPetty  RGTien  AY Medial and superior temporal gyrus volumes and cerebral asymmetry in schizophrenia versus bipolar disorder. Biol Psychiatry. 1997;411- 14
Link to Article
Oldfield  RC The assessment and analysis of handedness: The Edinburg Inventory. Neuropsychologia. 1971;997- 113
Link to Article
Spitzer  RLWilliams  JBWGibbson  MFirst  M The Structured Clinical Interview for DSM-III-R (SCID).  Washington, DC American Psychiatric Association1990;
Spitzer  RLWilliams  JBWGibbson  MFirst  M The Structured Clinical Interview for DSM-III-R (SCID-NP)—Non-Patient Edition.  Washington, DC American Psychiatric Association1990;
Spitzer  RLWilliams  JBWGibbson  MFirst  M The Structured Clinical Interview for DSM-III-R (SCID-II)—Personality Disorders.  Washington, DC American Psychiatric Association1990;
Wechsler  D Wechsler Adult Intelligence Scale–Revised.  New York, NY Harcourt Brace Jovanovich Inc1981;
Hollingshead  AB Two Factor Index of Social Position.  New Haven, Conn Yale University Press1965;
Overall  JEGorham  DR The Brief Psychiatric Rating Scale. Psychol Rep. 1962;10799- 812
Link to Article
Endicott  JSpitzer  RLFleiss  JLCohen  J The Global Assessment Scale: a procedure for measuring overall severity of psychiatric disturbance. Arch Gen Psychiatry. 1976;33766- 771
Link to Article
Shenton  MEKikinis  RJolesz  FAPollak  SDLeMay  MWible  CGHokama  HMartin  JMetcalf  DColeman  MMcCarley  RW Abnormalities of the left temporal lobe and thought disorder in schizophrenia: a quantitative magnetic resonance imaging study. N Engl J Med. 1992;327604- 612
Link to Article
Shenton  MEKikinis  RMcCarley  RWMetcalf  DTieman  JJolesz  FA Application of automated MRI volumetric measurement techniques to the ventricular system in schizophrenics and normal controls. Schizophr Res. 1991;5103- 113
Link to Article
Kikinis  RJolesz  FAGerig  G 3D morphometric and morphometric information derived from clinical brain MR images. Hohne  KHFuchs  HPizer  SMeds.3D Imaging in Medicine Berlin, Germany Springer-Verlag1990;441- 454
Zipursky  RBMarsh  LLim  KODeMent  SShear  PKSullivan  EVMurphy  GMCsernansky  JGPfefferbaum  A Volumetric MRI assessment of temporal lobe structures in schizophrenia. Biol Psychiatry. 1994;35501- 516
Link to Article
Dickey  CCMcCarley  RWVoglmaier  MNiznikiewicz  MSeidman  LJHirayasu  YFischer  IATeh  ERhoads  RVJakab  MKikinis  RJolesz  FAShenton  ME Schizotypal personality disorder and MRI abnormalities of temporal lobe gray matter. Biol Psychiatry. 1999;451393- 1402
Link to Article
Kay  SROpler  LAFiszbein  A Positive and Negative Syndrome Scale Manual.  North Tonawanda, NY Multi-Health Systems1992;
Holcomb  HHRitzl  EKMedoff  DRNevitt  JGordon  BTamminga  CA Tone discrimination performance in schizophrenic patients and normal volunteers: impact of stimulus presentation levels and frequency differences. Psychiatry Res. 1995;5775- 82
Link to Article
Javitt  DCDoneshka  PGrochowski  SRitter  W Impaired mismatch negativity generation reflects widespread dysfunction of working memory in schizophrenia. Arch Gen Psychiatry. 1995;52550- 558
Link to Article
Hirayasu  YPotts  GFO'Donnell  BFKwon  JArakaki  HAkdag  SJLevitt  JJMcCarley  RW Auditory mismatch negativity in schizophrenia: topographic evaluation with a high density recording montage. Am J Psychiatry. 1998;1551281- 1284
Barta  PEPearlson  GDPowers  RERichards  SSTune  LE Auditory hallucinations and smaller superior temporal gyral volume in schizophrenia. Am J Psychiatry. 1990;1471457- 1462
Schlaepfer  TEHarris  GJTien  AYPeng  LWLee  SFederman  EBChase  GABarta  PEPearlson  GD Decreased regional cortical gray matter volume in schizophrenia. Am J Psychiatry. 1994;151842- 848
Flaum  MSwayze  VW  IIO'Leary  DSYuh  WTEhrhardt  JCArndt  SVAndreasen  NC Effects of diagnosis, laterality, and gender on brain morphology in schizophrenia. Am J Psychiatry. 1995;152704- 714
Degreef  GAshtari  MBogerts  BBilder  RMJody  DNAlvir  JMLieberman  JA Volumes of ventricular system subdivisions measured from magnetic resonance images in first-episode schizophrenic patients. Arch Gen Psychiatry. 1992;49531- 537
Link to Article
Bilder  RMWu  HBogerts  BDegreef  GAshtari  MAlvir  JMSnyder  PJLieberman  JA Absence of regional hemispheric volume asymmetries in first-episode schizophrenia. Am J Psychiatry. 1994;1511437- 1447
Velakoulis  DPantelis  CMcGorry  PDDudgeon  PBrewer  WCook  MDesmond  PBridle  NTierney  PMurrie  VSingh  BCopolov  D Hippocampal volume in first-episode psychoses and chronic schizophrenia: a high-resolution magnetic resonance imaging study. Arch Gen Psychiatry. 1999;56133- 141
Link to Article
Zipursky  RBSeeman  MVBury  ALangevin  RWortzman  GKatz  R Deficits in gray matter volume are present in schizophrenia but not bipolar disorder. Schizophr Res. 1997;2685- 92
Link to Article
Harvey  IPersaud  RRon  MABaker  GMurray  RM Volumetric MRI measurements in bipolars compared with schizophrenics and healthy controls. Psychol Med. 1994;24689- 699
Link to Article

Figures

Place holder to copy figure label and caption
Figure 1.

A, Coronal slice (1.5 mm) through the temporal lobe of a healthy control subject. The regions of interest for the structures are outlined: the gray matter of Heschl gyrus (HG) is red on subject left and green on subject right. The gray matter of planum temporale (PT) is labeled yellow on subject left and blue on subject right. B, Top-down view of the 3-dimensional reconstruction of HG and PT placed on top of an axial magnetic resonance imaging slice. Anterior is top. The HG is red on subject left and green on subject right, and PT is blue on subject left and yellow on subject right. C, Three-dimensional reconstruction of the left and right regions of interest, color coded as in section B but from a slightly different angle of rotation from that in section B. Note the tubular structure of the gray matter of the superior temporal gyrus, most clearly seen anteriorly, where gray codes non-HG, non-PT portions of superior temporal gyrus. D, Three-dimensional reconstructions viewed from a different angle from that in section C (D1 is subject right and D2 is subject left).

Graphic Jump Location
Place holder to copy figure label and caption
Figure 2.

Relative volume of the Heschl gyrus and planum temporale in patients with first-episode schizophrenia, patients with first-episode mania, and healthy control subjects. Horizontal lines represent means.

Graphic Jump Location

Tables

Table Graphic Jump LocationTable 1. Subjects' Characteristics and Test Scores*
Table Graphic Jump LocationTable 2. Absolute and Relative Volumes of Regions of Interest of Heschl Gyrus and Planum Temporale*

References

Shenton  MEWible  CGMcCarley  RW A review of magnetic resonance imaging studies of brain abnormalities in schizophrenia. Krishnan  KRRDoraiswamy  PMeds.Brain Imaging in Clinical Psychiatry New York, NY Marcel Dekker Inc1997;297- 380
McCarley  RWWible  CGFrumin  MHirayasu  YLevitt  JJFischer  IAShenton  ME MRI anatomy of schizophrenia. Biol Psychiatry. 1999;451099- 1119
Link to Article
Shenton  MEFrumin  MMcCarley  RWMaier  SWestin  CFFischer  IADickey  CCKikinis  R MR morphometric findings in schizophrenia. Dougherty  DRauch  SRosenbaum  Jeds.Psychiatric Neuroimaging Strategies Research and Clinical Applications Washington, DC American Psychiatric Association2000;
Pearlson  GDMarsh  L Structural brain imaging in schizophrenia: a selective review. Biol Psychiatry. 1999;46627- 649
Link to Article
Marsh  LSuddath  RLHiggins  NWeinberger  DR Medial temporal lobe structures in schizophrenia: relationship of size to duration of illness. Schizophr Res. 1994;11225- 238
Link to Article
Kwon  J-SMcCarley  RWHirayasu  YAnderson  JEFischer  IAKikinis  RJolesz  FAShenton  ME Left planum temporale volume reduction in schizophrenia. Arch Gen Psychiatry. 1999;56142- 148
Link to Article
Petty  RGBarta  PEPearlson  GDMcGilchrist  IKLewis  RWTien  AYPulver  AVaughn  DDCasanova  MFPowers  RE Reversal of asymmetry of the planum temporale in schizophrenia. Am J Psychiatry. 1995;152715- 721
Rossi  ASerio  AStratta  PPetruzzi  CSchiazza  GMancini  FCasacchia  M Planum temporale asymmetry and thought disorder in schizophrenia. Schizophr Res. 1994;121- 7
Link to Article
Jacobsen  LKGiedd  JNTanrikut  CBrady  DRDonohue  BCHamburger  SDKumra  SAlaghband-Rad  JRumsey  JMRapoport  JL Three-dimensional cortical morphometry of the planum temporale in childhood-onset schizophrenia. Am J Psychiatry. 1997;154685- 687
DeLisi  LEHoff  ALNeale  CKushner  M Asymmetries in the superior temporal lobe in male and female first-episode schizophrenic patients: measures of the planum temporale and superior temporal gyrus by MRI. Schizophr Res. 1994;1219- 28
Link to Article
Kleinschmidt  AFalkai  PHuang  YSchneider  TFurst  GSteinmetz  H In vivo morphometry of planum temporale asymmetry in first-episode schizophrenia. Schizophr Res. 1994;129- 18
Link to Article
Kulynych  JJVladar  KFantie  BDJones  DWWeinberger  DR Normal asymmetry of the planum temporale in patients with schizophrenia: three-dimensional cortical morphometry with MRI. Br J Psychiatry. 1995;166742- 749
Link to Article
Frangou  SSharma  TSigmudsson  TBarta  PPearlson  GMurray  RM The Maudsley Family Study, 4: normal planum temporale asymmetry in familial schizophrenia: a volumetric MRI study. Br J Psychiatry. 1997;170328- 333
Link to Article
Barta  PEPearlson  GDBrill  LB  IIRoyall  RMcGilchrist  IKPulver  AEPowers  RECasanova  MFTien  AYFrangou  SPetty  RG Planum temporale asymmetry reversal in schizophrenia: replication and relationship to gray matter abnormalities. Am J Psychiatry. 1997;154661- 667
Galaburda  AMCorsiglia  JRosen  GDSherman  GF Planum temporale asymmetry, reappraisal since Geschwind and Levitsky. Neuropsychologia. 1987;25853- 868
Link to Article
Geschwind  NLevitsky  W Human brain: left-right asymmetries in temporal speech region. Science. 1968;161186- 187
Link to Article
Witelson  SFPallie  W Left hemisphere specialization for language in the newborn: neuroanatomical evidence of asymmetry. Brain. 1973;96641- 646
Link to Article
Falkai  PBogerts  BSchneider  TGreve  BPfeiffer  UPilz  KGonsiorzcyk  CMajtenyi  COvary  I Disturbed planum temporale asymmetry in schizophrenia: a quantitative post-mortem study. Schizophr Res. 1995;14161- 176
Link to Article
Barta  PEPetty  RGMcGilchrist  ILewis  RWJerram  MCasanova  MFPowers  REBrill  LB  IIPearlson  GD Asymmetry of the planum temporale: methodological considerations and clinical associations. Psychiatry Res. 1995;61137- 150
Link to Article
Musiek  FEReeves  AG Asymmetries of the auditory areas of the cerebrum. J Am Acad Audiol. 1990;1240- 245
Rojas  DCTeale  PSheeder  JSimon  JReite  M Sex-specific expression of Heschl's gyrus functional and structural abnormalities in paranoid schizophrenia. Am J Psychiatry. 1997;1541655- 1662
Crow  TJ The two-syndrome concept: origins and current status. Schizophr Bull. 1985;11471- 486
Link to Article
Hirayasu  YShenton  MESalisbury  DFDickey  CCFischer  IAMazzoni  PKisler  TArakaki  HKwon  JSAnderson  JEYurgelun  TTohen  MMcCarley  RW Lower left temporal lobe MRI volumes in patients with first-episode schizophrenia compared with psychotic patients with first-episode affective disorder and normal subjects. Am J Psychiatry. 1998;1551384- 1391
Pearlson  GDBarta  PEPowers  REMenon  RRRichards  SSAylward  HFederman  BChase  GAPetty  RGTien  AY Medial and superior temporal gyrus volumes and cerebral asymmetry in schizophrenia versus bipolar disorder. Biol Psychiatry. 1997;411- 14
Link to Article
Oldfield  RC The assessment and analysis of handedness: The Edinburg Inventory. Neuropsychologia. 1971;997- 113
Link to Article
Spitzer  RLWilliams  JBWGibbson  MFirst  M The Structured Clinical Interview for DSM-III-R (SCID).  Washington, DC American Psychiatric Association1990;
Spitzer  RLWilliams  JBWGibbson  MFirst  M The Structured Clinical Interview for DSM-III-R (SCID-NP)—Non-Patient Edition.  Washington, DC American Psychiatric Association1990;
Spitzer  RLWilliams  JBWGibbson  MFirst  M The Structured Clinical Interview for DSM-III-R (SCID-II)—Personality Disorders.  Washington, DC American Psychiatric Association1990;
Wechsler  D Wechsler Adult Intelligence Scale–Revised.  New York, NY Harcourt Brace Jovanovich Inc1981;
Hollingshead  AB Two Factor Index of Social Position.  New Haven, Conn Yale University Press1965;
Overall  JEGorham  DR The Brief Psychiatric Rating Scale. Psychol Rep. 1962;10799- 812
Link to Article
Endicott  JSpitzer  RLFleiss  JLCohen  J The Global Assessment Scale: a procedure for measuring overall severity of psychiatric disturbance. Arch Gen Psychiatry. 1976;33766- 771
Link to Article
Shenton  MEKikinis  RJolesz  FAPollak  SDLeMay  MWible  CGHokama  HMartin  JMetcalf  DColeman  MMcCarley  RW Abnormalities of the left temporal lobe and thought disorder in schizophrenia: a quantitative magnetic resonance imaging study. N Engl J Med. 1992;327604- 612
Link to Article
Shenton  MEKikinis  RMcCarley  RWMetcalf  DTieman  JJolesz  FA Application of automated MRI volumetric measurement techniques to the ventricular system in schizophrenics and normal controls. Schizophr Res. 1991;5103- 113
Link to Article
Kikinis  RJolesz  FAGerig  G 3D morphometric and morphometric information derived from clinical brain MR images. Hohne  KHFuchs  HPizer  SMeds.3D Imaging in Medicine Berlin, Germany Springer-Verlag1990;441- 454
Zipursky  RBMarsh  LLim  KODeMent  SShear  PKSullivan  EVMurphy  GMCsernansky  JGPfefferbaum  A Volumetric MRI assessment of temporal lobe structures in schizophrenia. Biol Psychiatry. 1994;35501- 516
Link to Article
Dickey  CCMcCarley  RWVoglmaier  MNiznikiewicz  MSeidman  LJHirayasu  YFischer  IATeh  ERhoads  RVJakab  MKikinis  RJolesz  FAShenton  ME Schizotypal personality disorder and MRI abnormalities of temporal lobe gray matter. Biol Psychiatry. 1999;451393- 1402
Link to Article
Kay  SROpler  LAFiszbein  A Positive and Negative Syndrome Scale Manual.  North Tonawanda, NY Multi-Health Systems1992;
Holcomb  HHRitzl  EKMedoff  DRNevitt  JGordon  BTamminga  CA Tone discrimination performance in schizophrenic patients and normal volunteers: impact of stimulus presentation levels and frequency differences. Psychiatry Res. 1995;5775- 82
Link to Article
Javitt  DCDoneshka  PGrochowski  SRitter  W Impaired mismatch negativity generation reflects widespread dysfunction of working memory in schizophrenia. Arch Gen Psychiatry. 1995;52550- 558
Link to Article
Hirayasu  YPotts  GFO'Donnell  BFKwon  JArakaki  HAkdag  SJLevitt  JJMcCarley  RW Auditory mismatch negativity in schizophrenia: topographic evaluation with a high density recording montage. Am J Psychiatry. 1998;1551281- 1284
Barta  PEPearlson  GDPowers  RERichards  SSTune  LE Auditory hallucinations and smaller superior temporal gyral volume in schizophrenia. Am J Psychiatry. 1990;1471457- 1462
Schlaepfer  TEHarris  GJTien  AYPeng  LWLee  SFederman  EBChase  GABarta  PEPearlson  GD Decreased regional cortical gray matter volume in schizophrenia. Am J Psychiatry. 1994;151842- 848
Flaum  MSwayze  VW  IIO'Leary  DSYuh  WTEhrhardt  JCArndt  SVAndreasen  NC Effects of diagnosis, laterality, and gender on brain morphology in schizophrenia. Am J Psychiatry. 1995;152704- 714
Degreef  GAshtari  MBogerts  BBilder  RMJody  DNAlvir  JMLieberman  JA Volumes of ventricular system subdivisions measured from magnetic resonance images in first-episode schizophrenic patients. Arch Gen Psychiatry. 1992;49531- 537
Link to Article
Bilder  RMWu  HBogerts  BDegreef  GAshtari  MAlvir  JMSnyder  PJLieberman  JA Absence of regional hemispheric volume asymmetries in first-episode schizophrenia. Am J Psychiatry. 1994;1511437- 1447
Velakoulis  DPantelis  CMcGorry  PDDudgeon  PBrewer  WCook  MDesmond  PBridle  NTierney  PMurrie  VSingh  BCopolov  D Hippocampal volume in first-episode psychoses and chronic schizophrenia: a high-resolution magnetic resonance imaging study. Arch Gen Psychiatry. 1999;56133- 141
Link to Article
Zipursky  RBSeeman  MVBury  ALangevin  RWortzman  GKatz  R Deficits in gray matter volume are present in schizophrenia but not bipolar disorder. Schizophr Res. 1997;2685- 92
Link to Article
Harvey  IPersaud  RRon  MABaker  GMurray  RM Volumetric MRI measurements in bipolars compared with schizophrenics and healthy controls. Psychol Med. 1994;24689- 699
Link to Article

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