0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Letters to the Editor |

Genetic Determinants of Clozapine-Induced Agranulocytosis: Recent Results of HLA Subtyping in a Non-Jewish Caucasian Sample

Michael Dettling, MD; Ingolf Cascorbi, MD, PhD; Ivar Roots, MD; Bruno Mueller-Oerlinghausen, MD
Arch Gen Psychiatry. 2001;58(1):93-94. doi:10.1001/archpsyc.58.1.93.
Text Size: A A A
Published online

Extract

The incidence of agranulocytosis in clozapine-treated patients is comparatively high despite the undisputed clinical advantages of clozapine.1 The mechanisms of clozapine-induced agranulocytosis (CA) are debatable2; however, there are some findings indicative of an idiosyncratic drug reaction, pointing to a genetic basis of this adverse effect.3 Some studies suggest that specific HLA haplotypes are associated with a patient's susceptibility to developing CA.48 In these studies, HLA subtyping of Jewish and non-Jewish Caucasian patients with and without CA was performed. Clozapine-induced agranulocytosis was associated with HLA-B38, DRB1*0402, DRB4*0101, DQB1*0201, and DQB1*0302 haplotypes in Jewish and HLA-DR*02, DRB1*1601, DRB5*02, and DQB1*0502 in non-Jewish Caucasian patients47; the presence of HLA-B35 seemed to be a protective factor against CA in the latter group.8 However, each of these studies had statistical and/or methological shortcomings, such as small sample size, lack of clinical descriptions of study subjects, or insufficient information about the study design.

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Correspondence

CME
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Web of Science® Times Cited: 40

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();