The incidence of agranulocytosis in clozapine-treated patients is comparatively high despite the undisputed clinical advantages of clozapine.1 The mechanisms of clozapine-induced agranulocytosis (CA) are debatable2; however, there are some findings indicative of an idiosyncratic drug reaction, pointing to a genetic basis of this adverse effect.3 Some studies suggest that specific HLA haplotypes are associated with a patient's susceptibility to developing CA.4- 8 In these studies, HLA subtyping of Jewish and non-Jewish Caucasian patients with and without CA was performed. Clozapine-induced agranulocytosis was associated with HLA-B38, DRB1*0402, DRB4*0101, DQB1*0201, and DQB1*0302 haplotypes in Jewish and HLA-DR*02, DRB1*1601, DRB5*02, and DQB1*0502 in non-Jewish Caucasian patients4- 7; the presence of HLA-B35 seemed to be a protective factor against CA in the latter group.8 However, each of these studies had statistical and/or methological shortcomings, such as small sample size, lack of clinical descriptions of study subjects, or insufficient information about the study design.
Thank you for submitting a comment on this article. It will be reviewed by JAMA Psychiatry editors. You will be notified when your comment has been published. Comments should not exceed 500 words of text and 10 references.
Do not submit personal medical questions or information that could identify a specific patient, questions about a particular case, or general inquiries to an author. Only content that has not been published, posted, or submitted elsewhere should be submitted. By submitting this Comment, you and any coauthors transfer copyright to the journal if your Comment is posted.
* = Required Field
Disclosure of Any Conflicts of Interest*
Indicate all relevant conflicts of interest of each author below, including all relevant financial interests, activities, and relationships within the past 3 years including, but not limited to, employment, affiliation, grants or funding, consultancies, honoraria or payment, speakers’ bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued. If all authors have none, check "No potential conflicts or relevant financial interests" in the box below. Please also indicate any funding received in support of this work. The information will be posted with your response.
Some tools below are only available to our subscribers or users with an online account.
Download citation file:
Web of Science® Times Cited: 40
Customize your page view by dragging & repositioning the boxes below.
More Listings atJAMACareerCenter.com >
Enter your username and email address. We'll send you a link to reset your password.
Enter your username and email address. We'll send instructions on how to reset your password to the email address we have on record.
Athens and Shibboleth are access management services that provide single sign-on to protected resources. They replace the multiple user names and passwords necessary to access subscription-based content with a single user name and password that can be entered once per session. It operates independently of a user's location or IP address. If your institution uses Athens or Shibboleth authentication, please contact your site administrator to receive your user name and password.