THE TREATMENT of substance abuse has a history of developing "ideal" treatments that few patients are willing to take, such as disulfiram for alcoholism and naltrexone for opioid dependence. Despite its safety, few adverse effects, and infrequent dosing advantages, most heroin addicts shun naltrexone and prefer methadone maintenance.1- 3 Similarly, alcoholics shun disulfiram. Thus, we are cautiously optimistic about the therapeutic promise of this first report demonstrating cannabinoid receptor antagonism by Huestis et al.4 However, treatments developed for one disorder often end up showing greater use for another. Thus, naltrexone has shown greater utility for alcoholism than opioid dependence, and disulfiram may have greater utility for cocaine dependence than alcoholism.2- 5 The study by Huestis et al4 builds on a burgeoning preclinical knowledge about cannabinoid pharmacology and has promising implications for neuropsychiatric disorders involving cannabinoid receptor dysfunction.
Thank you for submitting a comment on this article. It will be reviewed by JAMA Psychiatry editors. You will be notified when your comment has been published. Comments should not exceed 500 words of text and 10 references.
Do not submit personal medical questions or information that could identify a specific patient, questions about a particular case, or general inquiries to an author. Only content that has not been published, posted, or submitted elsewhere should be submitted. By submitting this Comment, you and any coauthors transfer copyright to the journal if your Comment is posted.
* = Required Field
Disclosure of Any Conflicts of Interest*
Indicate all relevant conflicts of interest of each author below, including all relevant financial interests, activities, and relationships within the past 3 years including, but not limited to, employment, affiliation, grants or funding, consultancies, honoraria or payment, speakers’ bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued. If all authors have none, check "No potential conflicts or relevant financial interests" in the box below. Please also indicate any funding received in support of this work. The information will be posted with your response.
Some tools below are only available to our subscribers or users with an online account.
Download citation file:
Web of Science® Times Cited: 6
Customize your page view by dragging & repositioning the boxes below.
More Listings atJAMACareerCenter.com >
Enter your username and email address. We'll send you a link to reset your password.
Enter your username and email address. We'll send instructions on how to reset your password to the email address we have on record.
Athens and Shibboleth are access management services that provide single sign-on to protected resources. They replace the multiple user names and passwords necessary to access subscription-based content with a single user name and password that can be entered once per session. It operates independently of a user's location or IP address. If your institution uses Athens or Shibboleth authentication, please contact your site administrator to receive your user name and password.