0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Letters to the Editor |

Leptin as a Possible Modulator of Craving for Alcohol

Holger Jahn, MD; Michael Kellner, MD; Dieter Naber, MD; Klaus Wiedemann, MD; Falk Kiefer, MD
Arch Gen Psychiatry. 2001;58(5):509-510. doi:10.1001/archpsyc.58.5.509.
Text Size: A A A
Published online

Extract

Whereas the psychological construct and pathophysiological basis of craving for alcohol, a major risk for relapse in alcoholism, has been intensively evaluated in recent years, no measurable biological correlate exists.1 Neurobiological and psychological similarities between craving and appetite are well established since both are known to be influenced by the mesolimbic brain reward system and its endorphinergic inputs.2 Recently, leptin, the protein product of the obesity gene, was proposed to be a signal responsible for linking adipose stores with hypothalamic centers regulating energy homeostasis and body weight.3 In addition, leptin has been shown to alter the gene expression of corticotropin-releasing hormone and pro-opiomelanocortin in the hypothalamus, suggesting a role both in regulating the stress hormone axis and possibly in the endorphinergic modulation of the reward system.4 Leptin mutually interacts with other neuroendocrine systems involved in the regulation of appetite such as NPY (neuropeptide Y)3 or the newly discovered hypothalamic peptide CART (cocaine- and amphetamine-regulated transcript).5

Figures in this Article

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

First Page Preview

View Large
First page PDF preview

Figures

Place holder to copy figure label and caption

Relationship between body mass–corrected plasma leptin (as the ratio of plasma leptin and body mass index [BMI], calculated as weight in kilograms divided by the square of height in meters), plasma cortisol, and self-rated craving for alcohol in a sample of 20 subjects with alcohol dependency at the first day after onset of withdrawal. Pearson product moment correlation of the leptin-BMI ratio with craving was r = 0.68 (P<.04) with no correlation of leptin with cortisol or cortisol with craving. Partial correlation of the leptin-BMI ratio with craving controlling for cortisol was r = 0.54 (P<.02). VAS indicates visual analog scale.

Graphic Jump Location

Tables

References

Correspondence

CME
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Web of Science® Times Cited: 37

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();