Functional brain imaging studies of major depressive disorder (MDD) have demonstrated abnormal activity in prefrontal cortex (PFC), anterior cingulate gyrus, and the temporal lobe that normalizes with treatment. Using positron emission tomography, Brody et alArticle compared subjects with MDD with normal controls at baseline and examined changes in regional brain activity from before to after treatment with either medication (paroxetine) or interpersonal psychotherapy. Subjects with MDD had higher normalized activity than controls at baseline in PFC, caudate, and thalamus, and lower activity in the temporal lobe. These abnormalities tended to normalize with treatment. Regional changes appeared similar with both forms of treatment.