Schizotypal personality disorder (SPD) shares many of the symptoms of schizophrenia. However, unlike in schizophrenia, SPD patients do not have long term, active psychotic symptoms. Shihabuddin et alArticle used magnetic resonance imaging (MRI) and positron emission tomography (PET) to study the size and metabolic rate of the striatum, an area that has been associated with psychotic symptoms, in individuals with SPD, schizophrenia, and controls. Patients with SPD had reduced size and elevated metabolic rate in parts of the striatum. These alterations may be related to the sparing of patients with SPD from frank psychosis and suggest that SPD is associated with different brain chemistry.