It has been suggested that cerebrovascular disease may favor the development
of late-onset depression, and that the particular forms of vascular depression
should be individualized.1,2
This suggestion was supported by studies reporting an association between
clinically defined vascular risk factors and depression,1
as well as by the frequent occurrence of silent stroke and white matter changes
detected by neuroimaging in late-onset depression.2
However, the role of the polymorphism of apolipoprotein E (APOE) in the emergence of vascular depression is still unknown. The APOEϵ4 allele (APOEϵ4)
was shown to be a risk factor for Alzheimer disease (AD),3
but the association of this allele with depression4- 6
or with cerebrovascular disease7,8
remains controversial. The objective of the present study was, therefore,
to clarify the relationship between APOEϵ4 and
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