Nurnberger et al Article providea large, comprehensive report on psychiatric disorders in the relatives ofsubjects with alcohol dependence, using data from the Collaborative Studyof the Genetics of Alcoholism (COGA). Disorders aggregating in relatives includedalcohol dependence, as well as dependence on cocaine, marijuana, opiates,sedatives, stimulants, and tobacco. However, diagnoses of substance abusewere not increased. Other disorders aggregating in relatives included majordepression, panic disorder, posttraumatic stress disorder, obsessive compulsivedisorder, and antisocial personality disorder. These findings suggest newstrategies for investigating the heterogeneity of alcohol dependence, andthey imply shared vulnerability factors for alcohol dependence and multiplepsychiatric disorders.