Stewart and colleagues1 provided compelling evidence for the association between depressive symptoms and the progression of subclinical atherosclerosis. In a 3-year study, they found that higher levels of depressive symptoms (eg, anhedonia, fatigue, and sleep/appetite disturbance) at baseline were associated with a greater 3-year change in carotid intima-media thickness (IMT), and they suggested that depression may play a role in the earlier stages of the development of coronary artery disease. They acknowledged that it is unlikely that the symptoms per se are the pathobiological mechanism of atherosclerosis. A likely explanation for the observed association between depressive symptoms and atherosclerosis is that both are triggered and/or maintained by a common biological mechanism. The Stewart et al study1 included only healthy, older individuals, and the authors suspect that the association they observed may be specific to this population. A putative common mechanism that is affected by aging and may link depression and atherosclerosis has recently been discussed.2 This mechanism is the pathway of the inflammatory enzyme 5-lipoxygenase (5-LOX).
Thank you for submitting a comment on this article. It will be reviewed by JAMA Psychiatry editors. You will be notified when your comment has been published. Comments should not exceed 500 words of text and 10 references.
Do not submit personal medical questions or information that could identify a specific patient, questions about a particular case, or general inquiries to an author. Only content that has not been published, posted, or submitted elsewhere should be submitted. By submitting this Comment, you and any coauthors transfer copyright to the journal if your Comment is posted.
* = Required Field
Disclosure of Any Conflicts of Interest*
Indicate all relevant conflicts of interest of each author below, including all relevant financial interests, activities, and relationships within the past 3 years including, but not limited to, employment, affiliation, grants or funding, consultancies, honoraria or payment, speakers’ bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued. If all authors have none, check "No potential conflicts or relevant financial interests" in the box below. Please also indicate any funding received in support of this work. The information will be posted with your response.
Some tools below are only available to our subscribers or users with an online account.
Download citation file:
Web of Science® Times Cited: 11
Customize your page view by dragging & repositioning the boxes below.
More Listings atJAMACareerCenter.com >
Enter your username and email address. We'll send you a link to reset your password.
Enter your username and email address. We'll send instructions on how to reset your password to the email address we have on record.
Athens and Shibboleth are access management services that provide single sign-on to protected resources. They replace the multiple user names and passwords necessary to access subscription-based content with a single user name and password that can be entered once per session. It operates independently of a user's location or IP address. If your institution uses Athens or Shibboleth authentication, please contact your site administrator to receive your user name and password.