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Evidence of a Plasma Factor in Schizophrenia

CHARLES E. FROHMAN, Ph.D.; L. KENNETH LATHAM; PETER G. S. BECKETT, M.B.; JACQUES S. GOTTLIEB, M.D.
AMA Arch Gen Psychiatry. 1960;2(3):255-262. doi:10.1001/archpsyc.1960.03590090011003.
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Recent work in this laboratory has indicated that a defect exists in the mechanism of control of energy metabolism in the blood of the schizophrenic patient.1-3 This defect is more apparent following stress. The control subjects after insulin stress showed an increase in specific activity of adenosinetriphosphate (ATP) isolated one hour after blood was incubated in vitro with P32O4. No such increase with stress occurred in the chronic schizophrenic patients. Since ATP must be formed within the cell concurrently with the release of energy from metabolites, it may be assumed that, upon being stressed by insulin, the cells from the schizophrenic subjects do not increase their rate of energy production in the same manner as do those from control subjects.

In the following experiments this defect was further studied in schizophrenic patients and control subjects before and after insulin stress, measuring the

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