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Differential Extraction of Indoles from the Urine of Schizophrenic and Normal Subjects

HERBERT SPRINCE, Ph.D.; ENOCH HOUSER, M.S.; DOROTHY JAMESON, B.A.; F. CURTIS DOHAN, M.D.
AMA Arch Gen Psychiatry. 1960;2(3):268-270. doi:10.1001/archpsyc.1960.03590090024005.
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Abnormal excretion of urinary indoles has long been implicated in mental illness. This has become well defined in two hereditary diseases with mental symptoms, namely, phenylketonuria1 and H (Hartnup) disease.2 Attempts to relate schizophrenia to indole metabolism have been inconclusive. Recent studies, however, have revealed certain Ehrlich-benzaldehyde-reacting spots, which occur more frequently, or with greater intensity, on paper chromatograms of urine from schizophrenic patients than from those of normal subjects.3-5 One such spot has been found by several investigators independently. On paper chromatograms sprayed with Ehrlich’s benzaldehyde reagent (EBR) it gives an azure-blue color and is easily located by its characteristic position in relation to urea and indoxylsulfate.4,5

The purpose of this report is twofold: (1) to describe a method for the differential extraction of indoles from urine, including the above-mentioned spot, and (2) to present results of chromatographing extracts obtained

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