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Treatment of Schizophrenia with Septal Extract

GARFIELD TOURNEY, M.D.; PETER G. S. BECKETT, M.D.; RITA SENF, Ph.D.; CHARLES FROHMAN, Ph.D.; JACQUES S. GOTTLIEB, M.D.; Robert G. Heath, M.D.
Arch Gen Psychiatry. 1960;3(6):646-649. doi:10.1001/archpsyc.1960.01710060078011.
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Introduction  In line with Heath's hypothesis that the septal region of the brain produces an abnormal type of electrical activity in schizophrenic patients, he has postulated that a deficiency in some factor, probably humoral, in this area may account for the symptomatology of schizophrenia. In attempting to alleviate this hypothesized deficiency, he has administered a specially prepared extract of the septal region of cattle brain as a treatment for schizophrenia.1 Although Heath has made no formal report regarding the efficacy of septal extract (see Addendum by Dr. Heath to present paper), there has been much discussion in psychiatric circles regarding its value.In order to clarify various impressions, a careful double-blind evaluation was made of septal extract in the treatment of schizophrenia.

Methods  Clinical Subjects.—This study has been approached in two ways. In the first part of the study 10 schizophrenic patients were evaluated, 8 of these being chronic and 2 acute. The chronic schizophrenic patients had

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