This monograph is in 2 parts. The first part is a catamnestic study of 299 patients on whom a frontal leukotomy had been made by the standard Freeman-Watts method. Of these patients 255 were schizophrenics, 21 of whom were also mentally defective; the remainder were of various categories, too few of any one to be significant. The mortality of operation was 5%; 3.7% had postsurgical epileptic attacks. Of the schizophrenic group 26.6% were improved, 8.4% were worse, 48.2% were unaltered, and 16.8% showed slight transitory improvement. Since the time elapsed since operation varied from 1 to 12 years these figures do not have much meaning.
The second part is concerned with anatomoclinical correlation based on 32 patients who died at some time before the study was completed. Of these, 16 died during or immediately after the leukotomy; the others died anywhere from 2 months to 11 years later. Eight of