Clinical psychiatric experience demonstrates a wide variation in behavioral reactions to drugs. The necessity for systematic studies of patient-drug interactions has been emphasized by both the practical problem of the differential indications for selection of drugs, and the theoretic problem of understanding the mode of action of drug therapies.
Since it was our conviction that the several types of behavioral change in somatic therapy were related to personality patterns,3-6 it was necessary first to specify the behavioral change patterns. We wished to gain a broad image of the patient's behavior, avoiding simple lists of traits and symptoms. As an initial program, the use of psychotropic drugs throughout the Hospital was restricted, and prescribed only by a psychiatrist member of the Department of Experimental Psychiatry, at the request of the patient's therapist. Prior to starting medication, each patient was interviewed by a