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Excretion of 4-Amino-5-Imidazolecarboxamide by Mental Patients

P. L. McGEER, Ph.D., M.D.; E. G. McGEER, Ph.D.; J. E. BOULDING, M.D.
Arch Gen Psychiatry. 1963;8(4):418-422. doi:10.1001/archpsyc.1963.01720100108011.
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Introduction  The ribotide of 4-amino-5-imidazolecarboxamide is a key intermediate in the pathway of purine biosynthesis from glycine to inosinic acid.1 Some breakdown of the ribotide occurs, since the free base (AIC) has been identified in urine both by Vilenkina2 and in this laboratory.3 Our interest in AIC was first aroused by the appearance of an unidentified fading blue spot in chromatograms of extracts of schizophrenic urines sprayed with diazotized sulfanilic acid. After the identification of this spot as AIC, a colorimetric analysis was developed, and a program undertaken to determine its excretion in normal humans and in persons suffering from a variety of mental and physical disorders. Data on AIC excretion in mentally normal humans have been reported previously4,5 and are in general agreement with data obtained by Braunstein and Vilenkina,6,7 using a chromatographic method of analysis. This paper will report the data obtained on AIC excretion by mental patients.

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