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Phenothiazine Reduction As a Cause of Rehospitalization

Arch Gen Psychiatry. 1965;12(6):586-588. doi:10.1001/archpsyc.1965.01720360058009.
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WE RECENTLY studied a group of schizophrenic outpatients to find out if reduction in phenothiazine dosage, ordered by a physician, is a significant cause of readmission to a hospital.

Previous controlled studies have shown the deleterious effect, in schizophrenia, of withdrawing phenothiazines.1-8 Some of these have been of the type where the phenothiazine was withdrawn and replaced by a placebo1-7 with the patient's physician remaining "blind." In several of these studies readmission to a hospital has been used as a criterion of deterioration.2-4,8

It might be supposed that when the reduction in dosage is deliberately ordered by a physician, the deleterious results would be less likely than when the drug is capriciously stopped as part of a double-blind, placebo-controlled, experiment. (Analogy with other drugs, such as digitalis for heart failure, or steroids for rheumatoid arthritis, would certainly suggest this.) Forrest, however, has


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