0
Article |

Importance of Psychiatric Diagnosis in Prediction of Clinical Drug Effects

DONALD F. KLEIN, MD; GLEN OAKS
Arch Gen Psychiatry. 1967;16(1):118-126. doi:10.1001/archpsyc.1967.01730190120016.
Text Size: A A A
Published online

THE DEVELOPMENT of effective Psychopharmacological agents confronted the psychiatric profession with the inadequacy of its diagnostic system for the provision of rational indications and contraindications for drug therapy. Within each standard diagnostic group there are wide variations in drug-induced behavioral reactions. Therefore, clinical treatment with psychotropic agents has been governed by rule of thumb modified by trial and error. This paper will emphasize the utility of psychiatric diagnosis when appropriately modified for prediction of treatment outcome.

The issue of the prediction of drug effect is one of considerable practical and theoretical importance. It is difficult to arrive at generally valid conclusions predictive of drug effect from clinical empiricism because of spontaneous remissions, uncontrolled fluctuations of life circumstance, and the meager abilities of many psychiatric patients to describe objectively their level of cognitive, affective, and social functioning. Most systematic attempts to predict treatment

Topics

Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
/>
First page PDF preview

Figures

Tables

References

Correspondence

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();