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LSD and Psychiatric Inpatients

John D. Hensala, PhD, MD; Leon J. Epstein, MD, PhD; K. H. Blacker, MD
Arch Gen Psychiatry. 1967;16(5):554-559. doi:10.1001/archpsyc.1967.01730230038005.
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THE USE of lysergic acid diethylamide (LSD) in nonmedical settings is currently receiving a great deal of attention. Reports in the literature have indicated that such use of LSD can induce severe panic states and psychotic reactions.1-3 These reactions have at times been described as being dangerous to the individual taking the drug, as well as occasionally to those around him. The seriousness of these untoward reactions is documented by successful suicides, serious suicide attempts, and even a homicide.4,6 Occasional prolonged psychotic episodes have been described.7

The majority of studies published thus far of patients who ingested LSD and subsequently received psychiatric treatment have emphasized psychotic reactions, complications, and side-effects resulting from the drug. This study differs, however; it attempts to examine and define specific characteristics of hospitalized psychiatric patients with a history of LSD use, and to compare these patients with a


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