Article |

The Effects of Personality Type on Drug Response

Robert L. McDonald, MD
Arch Gen Psychiatry. 1967;17(6):680-686. doi:10.1001/archpsyc.1967.01730300040007.
Text Size: A A A
Published online

PARADOXICAL effects coincident with drug administration have been observed clinically for some years. The advent of psychochemotherapeutic agents during the last decade or so has resulted in a noticeable increase in the incidence of these reactions. Although these reactions have by no means been confined to any generic class, the most marked paradoxical responses have been reported in relation to phenothiazine usage where, not infrequently, patients become markedly more agitated and anxious, rather than calmer and less anxious as would be expected from the pharmacological properties of phenothiazines. An early observer of these reactions, Sarwer-Foner,1-3 hypothesized that "the typical pharmacological effect (of the tranquilizing drug) chemically removes or interferes with activities used by the patient as major defenses against unconscious underlying conflicts." Stated more specifically, persons who characteristically are outgoing and physically interactive with their environment will respond with


Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
First page PDF preview





Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.