This monograph is the first of an anticipated series on research and clinical studies in headache by international contributors. The editor-in-chief, Dr. A. Friedman, is well known in the field. He has accumulated a truly international editorial board of prominent names around the world, and the nine contributors to the first volume are also prominent in their own specific areas. There is no doubt that this monograph is authoritative.
Some of the articles are highly technical, but others are quite clinical. Perhaps one of the most interesting is written by F. Sicuteri of Florence on "Vasoneuroactive Substances and their Implications in Vascular Pain." He is the man who first reported on the clinical use of methysergide maleate. Although the article is quite technical, it is well worth reading. His general thesis is, "It may be that the central disturbances which always accompany an attack of