We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Chromosome Studies in Early Infantile Autism

Lewis L. Judd, MD; Arnold J. Mandell, M D
Arch Gen Psychiatry. 1968;18(4):450-457. doi:10.1001/archpsyc.1968.01740040066008.
Text Size: A A A
Published online


IN THE SEARCH for etiological consistencies in early infantile autism, hereditary factors have not been considered a salient feature in the clinical picture,1-7 nor have they appeared to be a very promising approach for research. A partial explanation for this is that the parents and the siblings of these children appear remarkably free of major mental illnesses and this fact would not tend to support the presence of genetic factors.

There is, however, an interesting but not fully documented finding that suggests a more prominent role for genetic influences in this illness. There are indications that extremely high concordance rates may exist among those homozygous twins who are afflicted with infantile autism. In 1957 Chapman reported three cases of identical twins, two recorded in the previous literature and one case of his own, who were concordant for early infantile autism.8 Vaillant, in 1963,


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.