THE KRAEPELINIAN concept that emotional disorder is due to metabolic dysfunction has received little substantiation. Durell and Schildkraut1 have reviewed the evidence relating psychiatric disorder to a broad range of metabolic disorders, including variation in thyroid function.
Bowman,2 in a study using 49 psychiatric patients and 12 controls, found manic and depressive patients to have lower proteinbound iodines (PBI's) than controls. However, manic patients had lower radioactive iodine (RAI) uptakes than controls, whereas depressive patients did not. Paranoid schizophrenic patients had higher PBI's than catatonic and other schizophrenics. No significant differences were found for basal metabolic rate (BMR) and plasma cholesterol.
A tendency for a wider range in a radioactively-determined index of thyroid activity in male schizophrenics, as compared with nonschizophrenic male psychiatric patients, was reported by Batt et al.3
Cranswick,4 in his study, found that 31 schizophrenic