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Reevaluation of Heterophile Hemolytic Response in Psychiatric Patients

Samuel Gershon, MBBS, DPM; Baron Shopsin, MD; John R. Bergen, PhD; Lorraine Pinckney, MT
Arch Gen Psychiatry. 1968;19(5):611-615. doi:10.1001/archpsyc.1968.01740110099011.
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IN 1947, Sjovall1 reported occurrence of hemoglobin in the urine of mice following injection of serum of schizophrenics and loss of this activity of serum following heating at 56 C for one half hour. Turner and Chipps pursued this lead and in 1966 reported2 that there is an antirabbit heterophil hemolysin of widespread occurrence in human serum. Their study indicated that this hemolysin was present at higher levels in the serum of schizophrenics than those of other persons.

The interest aroused by this notion of heterophil hemolysins as another3 potential "biochemical lesion" in schizophrenia prompted further investigation. Operating essentially within the same framework as Turner and Chipps, the data we collected fails to indicate a difference between schizophrenic and nonschizophrenic populations with respect to serum hemolysis of rabbit erythrocytes.

Methods  Blood was drawn in the morning from fasting subjects. One part of the


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