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Phobia Questionnaire Responses and Urine Catecholamines

Julius J. Chosy, MD; William C. Lewis, MD; David T. Graham, MD
Arch Gen Psychiatry. 1970;22(1):58-62. doi:10.1001/archpsyc.1970.01740250060009.
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MOST .OST psychoendocrine studies of the past have been characterized by comparison of stimulus conditions or clinical behavior ratings with endocrine measures. There are few studies in which objectively scored, self-administered psychological tests and chemical measurement of sympatho-adrenalmedullary output were combined.1,2 Measurement of affect in psycho endocrine investigation generally has been limited to the broad categories anxiety, anger, elation, and depression, with few attempts at further subdivision.

This is a report in which an objective, self-administered psychological test was used in an attempt to define the relationship of urine catecholamines to two subdivisions of anxiety. The specific aim was to find, in urine epinephrine and norepinephrine excretion, a chemical distinction that paralleled the psychological distinction between separation and body-harm anxiety. The research also provided an opportunity to correlate a measure of trait anxiety (as expressed in phobias) with urinary catecholamine excretion, in


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