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Manic Depressive Psychosis, Mental Retardation, and Chromosomal Rearrangement

George L. Adams, MD; Julian Kivowiz, MD; Eugene Ziskind, MD
Arch Gen Psychiatry. 1970;23(4):305-309. doi:10.1001/archpsyc.1970.01750040017003.
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THE CASE of an adolescent who presents the clinical findings of mental retardation, manic depressive psychosis, and a previously undescribed, unusual chromosomal rearrangement is reported. It is hoped that this paper will highlight discrepancies in our current state of knowledge and indicate the need for further research. The latter is especially relevant as psychiatrists begin to provide services for the mentally retarded.

Report of a Case  The patient is an 18-year-old white girl who was first brought to the UCLA Neuropsychiatric Institute in February 1969. Her present illness dates back approximately one year prior to her admission at which time she became progressively withdrawn, complained of lack of friends, and was noted by her parents to be more fearful with loss of self-confidence. She stated to her parents that she was "no good, I was never any good." She began doing progressively worse in school and became more introspective. Her


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