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Article | December 1970

Disruption of Myofibrils in the Skeletal Muscle of Psychotic Patients

D. A. Fischman, MD; Herbert Y. Meltzer, MD; R. W. Poppei, MD

Arch Gen Psychiatry. 1970;23(6):503-515. doi:10.1001/archpsyc.1970.01750060023003.

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ABSTRACT

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PREVIOUS studies from this laboratory^1-3 have demonstrated that an elevation of serum creatine phosphokinase (CPK, EC 2.7.3.2), of the muscle isozymic type, is found in approximately 60% of acutely psychotic patients at the onset of the acute psychotic episode. Evidence obtained by histochemical techniques⁴ revealed an abnormality of skeletal muscle in 44 of 64 acutely psychotic subjects. The histochemical pattern in these abnormal rasults of muscle biopsies was suggestive of a myopathic disorder.⁴ In this report, light and electron microscopic evidence is presented to indicate that substantial disruptive changes of the myofibrils occur in almost 40% of these psychotic patients, and these focal myofibrillar changes are compatible with a degenerative alteration of the muscle cell.

Methods

Subjects.— Skeletal muscle was obtained from a total of 83 human subjects. Ten of these subjects were normal controls; they had normal serum CPK activities, had no personal or family history

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Fischman DA, Meltzer HY, Poppei RW. Disruption of Myofibrils in the Skeletal Muscle of Psychotic Patients. Arch Gen Psychiatry. 1970;23(6):503-515. doi:10.1001/archpsyc.1970.01750060023003.

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