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Acetophenazine and Diazepam in Anxious Depressions

Leo E. Hollister, MD; John E. Overall, PhD; Alex D. Pokorny, MD; Jack Shelton, MD
Arch Gen Psychiatry. 1971;24(3):273-278. doi:10.1001/archpsyc.1971.01750090079012.
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Sixty-seven newly admitted depressed patients were classified on the basis of their presenting signs and symptoms as having the syndrome of anxious depression. They were assigned randomly either to treatment with the phenothiazine derivative, acetophenazine, or with the antianxiety drug, diazepam. After four weeks of treatment, both groups were equally improved. Study of the interactions between drugs and demographic variables revealed that patients with less long-term and uncomplicated depressions responded better to diazepam, the converse being true for acetophenazine. Although our previous studies indicated that phenothiazine derivatives were preferable to conventional tricyclic antidepressants in patients with anxious depressions, antianxiety agents are also effective. In fact, because most patients fall into the group which responds best to them, as well as because of their greater safety, drugs such as diazepam might be the first choice for treating the most common depressive syndrome, that of anxious depression.

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The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
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