Article |

Depressive Disease: Life Events and Onset of Illness

Remi J. Cadoret, MD; George Winokur, MD; Joe Dorzab, MD; Max Baker, MD
Arch Gen Psychiatry. 1972;26(2):133-136. doi:10.1001/archpsyc.1972.01750200037008.
Text Size: A A A
Published online

This study examines the relationship between various possible precipitating events and the onset of unipolar depressive illness in 100 patients. The precipitating factors studied were: (1) deprivation prior to age 16 as a result of loss of parents by death, separation or divorce; (2) personal losses through death in the year before admission; (3) threatened personal losses; and (4) physical illness in the preceding six months. Patients whose depressive illness started before age 40 had a significantly higher incidence of real or threatened personal losses than did later-onset depressives (after 40). Twelve patients claimed a personal loss preceding the onset of depressive symptoms. Using 51 well relatives of the patients, matched for age and sex as controls, two claimed a similar type of personal loss. The difference between the two incidences, patient 12% and control of 3.9%, is not statistically significant.


Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours





Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.