We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Learned Behavior and Limbic System Activity in Experimental Porphyria

Henry Lesse, MD; Lennart Wetterberg, MD
Arch Gen Psychiatry. 1972;27(1):119-124. doi:10.1001/archpsyc.1972.01750250103014.
Text Size: A A A
Published online


Allylisopropylacetamide (AIA), a porphyria-inducing compound, produces biochemical changes simulating those occurring in acute intermittent porphyria, an inborn error of metabolism characterized by neuropsychiatric symptoms. Little is known, however, about behavior or brain activity in experimental porphyria. Effects of AIA on performance of a discrimination task, on limbic system excitability, and on brain electroencephalographic activity were studied in cats. Small doses blocked learned reactions to environmental signals and to direct limbic system stimulation without impairing motility, sensory function, motivation, or level of arousal. Thresholds for evoking hippocampal after-discharges were markedly elevated. Additional behavioral aberrations and changes in brain electrical activity were induced by higher doses. Findings suggest that AIA decreases hippocampal excitability and interferes with ability to utilize certain signals which have acquired motivational significance during past learning experiences. This experimental model should prove helpful in studying neural and behavioral factors in the pathogenesis of acute porphyria.


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.