Cerebral electrotherapy (CET), electrosleep, is a mild electrical treatment developed in the USSR during the past 24 years and widely used in Eastern Europe. It has received little evaluation that would be considered rigorous by US standards. In this study of hormonal effects. seen with CET four days after beginning treatment in a series of 41 subjects, the serum thyroxine level showed a consistent rise with an increase in 28 and fall in 13 of 41 patients (p<.05). Among the male patients, ten of 20 showed substantial rises of 0.5μg/ 100 ml or more, and no patients showed similar decreases; there was much more variability in the female population. Changes in triiodothyronine resin uptake were not significant.
It is hypothesized that the changes observed (a) were not necessarily the cause of the clinical effects which may be seen and (b) were due to direct hypothalamic stimulation.