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Manic States:  A Genetic Study of Early and Late Onset Affective Disorders

Michael Taylor, MD; Richard Abrams, MD
Arch Gen Psychiatry. 1973;28(5):656-658. doi:10.1001/archpsyc.1973.01750350036007.
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Fifty manic probands were examined for age at first onset of affective illness, subsequent clinical course, any associated alcoholism, drug abuse, sociopathy or homosexuality. Information was obtained for all first-degree relatives for history and type of affective illness.

Onset of affective illness before age 30 was associated with a bipolar illness course, equal number of prior attacks of mania and depression, and a high prevalence of affective disorder, alcoholism, drug abuse, and sociopathy in first-degree relatives. Onset of affective illness after age 30 was associated with a unipolar manic course, excess prior attacks of mania, and a dearth of affective illness and associated conditions in first-degree relatives.

These data suggest that mania is not a single clinical entity and should not be used as the sole criterion for the diagnosis of bipolar illness.

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