We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Are There Pathognomonic Symptoms in Schizophrenia?  An Empiric Investigation of Schneider's First-Rank Symptoms

William T. Carpenter Jr., MD; John S. Strauss, MD; Salvatore Muleh
Arch Gen Psychiatry. 1973;28(6):847-852. doi:10.1001/archpsyc.1973.01750360069010.
Text Size: A A A
Published online


The need for operationalized criteria for the identification of schizophrenia is great. Schneider's diagnostic concept attempts the optimum in diagnostic clarity, using frequently occurring symptoms which can be reliably identified by various observers, and which he believes always indicate schizophrenia in the absence of an organic psychosyndrome. Schneider's approach, although never established by other investigators, is used for diagnosis throughout most of the world.

We found that the first-rank symptoms (FRSs) occurred frequently enough in acute schizophrenia to have diagnostic applicability. Individually, each FRS was found with greater frequency in schizophrenia. However, taken together, these symptoms which he considers pathognomonic of schizophrenia occur in one fourth of the cohort of manic-depressive patients. Therefore, Schneider's system for identifying schizophrenia, while highly discriminating, leads to significant diagnostic errors if FRSs are regarded as pathognomonic. Furthermore, FRSs did not have a postdictive or predictive function, as no relationship could be established between FRSs and duration or outcome of illness.


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.