We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

From Art to Science The Diagnosis and Treatment of Depression

William W. K. Zung, MD
Arch Gen Psychiatry. 1973;29(3):328-337. doi:10.1001/archpsyc.1973.04200030026004.
Text Size: A A A
Published online


In a review of the past and current literature on the classification of depression as a psychiatric disorder, it is apparent that diagnosis and treatment go hand-in-hand. The original Kraepelinian concept of dividing depression by etiological factors into endogenous and exogenous has persisted so that modern thinking in psychiatry still espouses aspects of this in various guises.

While the art of diagnosis and treatment may have declined, the science of diagnosis and treatment has made great strides with the advent of high-speed computers, sophisticated statistical analyses, and the birth of neuropsychopharmacology as a science.

I will summarize my own work on the formulation of an operational definition of depression as a disorder, its application into a rating instrument, the various validity and reliability studies performed, as well as clinical application of the rating scale.


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.