We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Effects of Electroconvulsive Seizures on Amine Metabolism in the Rat Brain

Michael H. Ebert, MD; Ross J. Baldessarini, MD; Joseph F. Lipinski, MD; Kenneth Berv, MD
Arch Gen Psychiatry. 1973;29(3):397-401. doi:10.1001/archpsyc.1973.04200030085013.
Text Size: A A A
Published online


Effects of acute and repeated electroconvulsive seizures (ECS) on amine metabolism in the rat brain were studied. Acute ECS increased the rate of disappearance of intracisternally injected [3H]norepinephrine (NE) and its conversion to [3H]normetanephrine as well as the disappearance of endogenous serotonin (5HT) and appearance of its major metabolite 5-hydroxyindoleacetic acid (5HIAA).

One day following a week of 14 ECS treatments, there was a small (<20%) increase in the rate of efflux of [3H]NE, which had disappeared by day 3. Increased turnover of 5HT was also found one day following a week of ECS, but this was no greater than occurred after the stress of handling alone. There were no changes in the levels of histamine after acute or repeated ECS. It seems unlikely that these effects bear an important relationship to the mechanisms of action of clinical ECT as used in the treatment of depression in patients.


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.