We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Liothyronine Treatment in Psychotic and Nonpsychotic Children Under 6 Years

Magda Campbell, MD; Barbara Fish, MD; Raphael David, MD; Theodore Shapiro, MD; Patrick Collins, PhD; Celedonia Koh, MD
Arch Gen Psychiatry. 1973;29(5):602-608. doi:10.1001/archpsyc.1973.04200050016003.
Text Size: A A A
Published online


Liothyronine sodium (Cytomel) was administered to 14 psychotic and six severely disturbed nonpsychotic euthyroid preschool-age children over a period of 11 to 19 weeks.

This controlled study explored the effects of liothyronine: it was found to be physiologically active and, as demonstrated by statistical analysis of ratings, is an effective therapeutic agent in both groups of children regardless of the level of motor activity. It had antipsychotic as well as stimulating properties.

All but six patients received short-term trials of dextroamphetamine sulfate (Dexedrine) to compare the effects of the two drugs. Dextroamphetamine was equally ineffective in hyper- and hypoactive psychotic patients. The behavioral and physiological effects of liothyronine in these "euthyroid" psychiatric patients are discussed, as well as its mechanism of action in psychotic children and adults in terms of possible thyroid dysfunction.


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.