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The Use of Cyclazocine in Treating Narcotic Addicts in a Low-Intervention Setting

Herbert Kleber, MD; J. Kevin Kinsella, EdD, MPH; Charles Riordan, MD; Sarah Greaves, MS; Donald Sweeney, PhD, MD
Arch Gen Psychiatry. 1974;30(1):37-42. doi:10.1001/archpsyc.1974.01760070023004.
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This study evaluated the clinical efficacy of cyclazocine when used as part of a direct-service drug-abuse program characterized by relatively low-treatment intervention. Standard induction and maintenance schedules were devised and procedures were developed to evaluate results.

Twenty-seven patients were administered cyclazocine over a tenmonth period with 42% being retained. Results suggest that, although cyclazocine was accepted by a majority (75%) of the sample, the nature and extent of side effects during induction may limit its usefulness of a larger scale. The overall program design holds promise as a model for future use of narcotic antagonists.


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