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Article |

Variability of the Clinical Course of Primary Affective Disorder

George E. Murphy, MD; Robert A. Woodruff Jr., MD; Marijan Herjanic, MD; Greg Super, MD
Arch Gen Psychiatry. 1974;30(6):757-761. doi:10.1001/archpsyc.1974.01760120023004.
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In a five-year prospective follow-up study, 37 patients were concordant for the diagnosis of primary affective disorder at index and blind follow-up interview. This report describes their clinical course graphically.

Six patients (16%) were chronically ill during the entire follow-up period. Nine (24%) had no recurrence of depression. The remaining 22 patients had one to nine further depressive episodes with durations varying from two weeks to one year.

At follow-up, 13 patients were ill: six chronically plus seven others. Three fourths of the patients were well more than three fourths of the time during the follow-up interval, with few or no lingering symptoms.


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