We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Repeat Administration of Marihuana Smoke to Humans

Pierre F. Renault, MD; Charles R. Schuster, PhD; Daniel X. Freedman, MD; Branimar Sikic, MD; Dorothy Nebel de Mello; Angelos Halaris, MD
Arch Gen Psychiatry. 1974;31(1):95-102. doi:10.1001/archpsyc.1974.01760130071012.
Text Size: A A A
Published online


Tolerance to marihuana was investigated in two experiments. Four men were given smoke from 435 mg of marihuana (1.5 Δ-9-tetrahydrocannabinol [THC]) twice a day for ten days preceded and followed by three days of a placebo twice a day; three additional men were given a higher dose (2.8% THC).

Time estimation was disrupted on the higher dose and gradually improved. Heart rate increase did not show tolerance. Enhancement of postural cradiovascular responses, when present, decreased in duration in three subjects. One developed a brief toxic psychosis, another pneumonitis of uncertain etiology. Dysphoric and psychotoxic effects were evident as a cumulative effect of the high dose.

Three additional men were given the low dosage once a week for six to eight weeks, and time estimation and heart rate changes were similar to those seen with frequent administration at that dose. Tolerance, recently reported in man, probably requires more frequent administration or a different dosage than the schedules employed here.


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.