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Stereospecific Actions of DOET (2,5-Dimethoxy-4-Ethylamphetamine) in Man

Solomon H. Snyder, MD; Sanford Unger, PhD; Robert Blatchley, MA; Charles F. Barfknecht, PhD
Arch Gen Psychiatry. 1974;31(1):103-106. doi:10.1001/archpsyc.1974.01760130079013.
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Several different molecular conformations of psychedelic drugs have been proposed to explain the very similar effects of drugs with markedly divergent chemical structures, such as mescaline and d-lysergic acid diethylamide (LSD). In some of these models, the α-carbon of methoxyamphetamine psychedelics approximates the asymmetric carbon No. 5 of LSD predicting that the (-) "R" isomer of the methoxyamphetamines should possess greater psychedelic activity than the ( + ) "S" isomer.

The present study reports a comparison of the psychotropic effects of isomers of DOET (2,5-dimethoxy-4-ethylamphetamine) a "psychedelic" methoxyamphetamine, in normal human subjects. The (-) "R" isomer is about four times as potent as the ( + ) "S" isomer, thus specifying the psychoactive conformation of the drug. This clinical study represents a novel approach to determining the molecular conformation of a drug at its receptor site.


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