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Chlordiazepoxide-Induced Hostility in a Small Group Setting

Carl Salzman, MD; Gerald E. Kochansky, PhD; Richard I. Shader, MD; Linda J. Porrino; Jerold S. Harmatz; Chester P. Swett Jr., MD
Arch Gen Psychiatry. 1974;31(3):401-405. doi:10.1001/archpsyc.1974.01760150103015.
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A small group model was used to examine the effects of chlordiazepoxide hydrochloride on affective and behavioral hostility in a social interactive setting. Three-person groups of male volunteers completed paper-and-pencil affective-rating scales individually and interacted with each other during a ten-minute discussion period that was videotaped and scored for behavioral hostility. The results indicated that chlordiazepoxide was associated with an increase in individual affective but not behavioral hostility. However, when a frustration stimulus was presented to the group, interpersonal behavioral hostility was increased in those who received chlordiazepoxide as compared with those taking a placebo. The data suggest that increases in hostility may be a regular rather than paradoxical effect of chlordiazepoxide. However, overt hostility may only become apparent in settings of interpersonal frustration.

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