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Amine Precursors and Depression

Joe Mendels, MD; James L. Stinnett, MD; David Burns, MD; Alan Frazer, PhD
Arch Gen Psychiatry. 1975;32(1):22-30. doi:10.1001/archpsyc.1975.01760190024002.
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The amino acid precursors, levodopa and L-tryptophan, were given to a group of hospitalized depressed patients in a double-blind placebo controlled study. Relatively large doses were not associated with sufficient clinical improvement to allow the patients to leave the hospital.

Previous studies using the precursor-load strategy have produced conflicting findings on the use of these compounds for depressed patients.

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