Operations at the clinical-research interface exert a signal influence on the therapy of patients being treated on investigative units. The effect on the treatment milieu has been described but the impactof a research climate on individual psychotherapy of hospitalized patients has not.
We observed research-therapy interaction in 25 acutely schizophrenic patients. Analytically oriented psychotherapy was carried outon a National Institutes of Health clinical research unit where drugs are only occasionally used, and patients are subjects in psychobiological investigation.
The subtle, and often neglected, interplay between therapy and research is examined, with emphasis on the shifting meanings of the patient's participation or refusal to participate in therapy, research, or both. A research transference and counter-transference are defined, and some special behavioral patterns of research patients receiving dynamic therapy are considered in this framework.