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Lithium Carbonate Response in Depression Prediction by Unipolar/Bipolar Illness, Average-Evoked Response, Catechol-O-Methyl Transferase, and Family History

Miron Baron, MD; Elliot S. Gershon, MD; Victor Rudy, MD; Wulff Z. Jonas; Monte Buchsbaum, MD
Arch Gen Psychiatry. 1975;32(9):1107-1111. doi:10.1001/archpsyc.1975.01760270039003.
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• The antidepressant efficacy of lithium carbonate was assessed in a double-blind trial in 23 hospitalized depressed patients. Unequivocal response was significantly more frequent in bipolar than in unipolar depressed patients. Lithium carbonate responders had a greater visual average-evoked response amplitude increase in response to increased stimulus intensity, termed "augmenting."

No correlation could be demonstrated between lithium carbonate efficacy and either erythrocyte catechol-O-methyl tramsferase activity, age of symptom onset, number of hospitalizations, or family history of affective disorders.


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