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Postpsychotic Depression in Schizophrenia

Thomas H. McGlashan, MD; William T. Carpenter Jr, MD
Arch Gen Psychiatry. 1976;33(2):231-239. doi:10.1001/archpsyc.1976.01770020065011.
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• Several authors have described a severe depression in patients emerging from psychotic states. The clinical picture usually resembles that of a retarded depression with strong neurasthenic and schizoid components. It frequently emerges after a patient has been discharged from the hospital and may often go unnoticed. When manifest, the syndrome is usually stable phenomenologically, is often lengthy, and may be resistant to all modalities of treatment. Postpsychotic depression is a relatively neglected clinical area despite the risk of suicide and prolonged suffering. Therapeutic perseverence purportedly can improve the patient's long-term prognosis, and the phenomenon itself may be a favorable prognostic sign. We present here a review and reformulation of this syndrome.


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