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Creatine Phosphokinase Levels in Children With Severe Developmental Disturbances

Donald J. Cohen, MD; Barbara K. Caparulo; J. Gerald Young, MD
Arch Gen Psychiatry. 1976;33(6):683-686. doi:10.1001/archpsyc.1976.01770060025004.
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• Serum creatine phosphokinase (CPK) levels were studied in 110 individuals: 40 psychotic children suffering from childhood autism, atypical personality development, and childhood schizophrenia; five children with childhood aphasia; 22 children with severe personality disorders; 29 normal children and normal siblings of psychotic children; and 14 normal parents of psychotic children.

Creatine phosphokinase levels from the entire population of adults and children were normally distributed, and the mean CPK levels for the eight diagnostic groups were within normal limits. Those 22 children with personality disorders had significantly higher CPK levels than the other diagnostic groups. This relatively higher level of CPK may be related to vulnerability to later development of schizophrenic spectrum disorders.

There was no apparent relationship between CPK levels and motor activity, nor was there any change in the level of CPK during a trial of psychoactive medication. Creatine phosphokinase levels remained relatively stable on test-retest determination.


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