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Cardiovascular and Subjective Effects of Intravenous Cocaine Administration in Humans

Marian W. Fischman, PhD; Charles R. Schuster, PhD; Leon Resnekov, MD; J. Fred E. Shick, MD; Norman A. Krasnegor, PhD; William Fennell, MD; Daniel X. Freedman, MD
Arch Gen Psychiatry. 1976;33(8):983-989. doi:10.1001/archpsyc.1976.01770080101010.
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• Nine volunteer subjects were tested with intravenously administered cocaine hydrochloride in doses ranging from 4 to 32 mg, as well as 10 mg of dextroamphetamine sulfate. Measures of cardiovascular and subjective effects were made. Generally parallel dose-effect functions were obtained for heart rate, blood pressure, Addiction Research Center Inventory scores, Profile of Mood Scales, and subject ratings. A substantial effect on each of these variables was recorded after 8 mg of cocaine. The increase continued and peaked at approximately 16 mg after which it usually leveled off. Ten milligrams of dextroamphetamine generally had an effect comparable to 8 to 16 mg of cocaine.


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