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Article |

Mortality in Depressed Patients Treated With Electroconvulsive Therapy and Antidepressants

David Avery, MD; George Winokur, MD
Arch Gen Psychiatry. 1976;33(9):1029-1037. doi:10.1001/archpsyc.1976.01770090019001.
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• The treatments of 519 depressed patients hospitalized from 1959 to 1969 were compared in a three-year follow-up study with particular reference to mortality. The electroconvulsive therapy (ECT) group had a significantly lower mortality than the inadequate antidepressant treatment group (P <.05) and the group that received neither ECT nor antidepressants (P <.025). Although the adequate antidepressant treatment group had a low mortality, statistically significant differences between this and other treatment groups could not be documented. Nonsuicidal deaths (P <.005), and particularly myocardial infarctions (P <.01), were significantly more frequent in the inadequately treated group compared to the adequately treated group. The superiority of adequate treatment is especially striking among men and among the older age groups. The results underscore the importance of adequate treatment of depression, especially in the older man.


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