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Abnormal-Pursuit Eye Movements in Schizophrenia:  Evidence for a Genetic Indicator

Philip S. Holzman, PhD; Einar Kringlen, MD; Deborah L. Levy, PhD; Leonard R. Proctor, MD; Shelby J. Haberman, PhD; Nicholas J. Yasillo
Arch Gen Psychiatry. 1977;34(7):802-805. doi:10.1001/archpsyc.1977.01770190064005.
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• Disordered smooth-pursuit eye movements occur in a high percentage of schizophrenic patients and their first-degree relatives. A test of the hypothesis that these disorders represent a genetic indicator of schizophrenia was undertaken by testing pursuit eye movements in a sample of monozygotic and dizygotic twins discordant for clinical schizophrenia. Deviant eye tracking is significantly concordant within monozygotic twin pairs, and less so within dizygotic twin pairs discordant for schizophrenia. A genetic interpretation is consistent with these results.

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