Article |

MMPI Assessment of Psychopathology in the Adopted-Away Offspring of Schizophrenics

Richard J. Haier, PhD; David Rosenthal, PhD; Paul H. Wender, MD
Arch Gen Psychiatry. 1978;35(2):171-175. doi:10.1001/archpsyc.1978.01770260049004.
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• Previous studies completed in Denmark show a higher frequency of schizophrenia-related psychopathology in the adopted offspring of schizophrenics than in matched controls. This study adds a psychometric dimension to the earlier reports with an analysis of psychopathology in the adopted offspring of schizophrenics based on the Minnesota Multiphasic Personality Inventory (MMPI). A combination of MMPI criteria and interviewbased diagnoses identifies 22% of the index cases and 6% of the control cases (P <.01) as having a schizophrenia spectrum disorder. The findings support a genetic hypothesis, but the use of the MMPI does not fully clarify some issues raised in the earlier reports.


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