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Article |

Color Blindness Not Closely Linked to Bipolar Illness Report of a New Pedigree Series

Elliot S. Gershon, MD; Steven D. Targum, MD; Steven Matthysse, PhD; William E. Bunney Jr, MD
Arch Gen Psychiatry. 1979;36(13):1423-1430. doi:10.1001/archpsyc.1979.01780130041005.
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• A new pedigree series of bipolar manic-depressive patients admitted to the National Institute of Mental Health intramural research program was evaluated for linkage between bipolar illness and red-green color blindness, since previous studies had indicated that close linkage was generally present. Using family study methods, six informative pedigrees were investigated. Analysis was performed using a multigenerational procedure and taking into account variable penetrance. Close linkage could be definitively ruled out as a general finding. Bipolar and related illnesses are thus not generally transmitted by a single major gene close to the protan/deutan region of the human X-chromosome.


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